Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent
Purpose: To investigate if a platelet inhibitor (aurintricarboxylic acid [ATA]) and a heparin-mimicking antagonist (RG-13577) of basic fibroblast growth factor 2 (bFGF2) could be combined as a stable compound and attached to conventional bare metal stents to hinder thrombus formation and inflammator...
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| Veröffentlicht in: | Journal of endovascular therapy 2006-02, Vol.13 (1), p.94-103 |
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| creator | Strehblow, Christoph Sperker, Wolfgang Hevesi, Akos Garamvölgyi, Rita Petrasi, Zsolt Shirazi, Maryam Sylvén, Christer Weiss, Thomas Lotan, Chaim Pugatsch, Thea Ben-Sasson, Shmuel A. Orlowski, Michael Glogar, Dietmar Gyöngyösi, Mariann |
| description | Purpose:
To investigate if a platelet inhibitor (aurintricarboxylic acid [ATA]) and a heparin-mimicking antagonist (RG-13577) of basic fibroblast growth factor 2 (bFGF2) could be combined as a stable compound and attached to conventional bare metal stents to hinder thrombus formation and inflammatory reactions of stenting.
Methods:
Fifteen domestic pigs were stented with RG-13577/ATA—coated (n=6), ATA-coated (n = 12), and bare metal stents (n = 12) in the left anterior descending (LAD) and left circumflex (LCX) coronary arteries. All surviving pigs were evaluated with contrast angiography and intravascular ultrasonography (IVUS) after 4 weeks. Histological analysis of the stented arteries was performed after hematoxylin-eosin staining. Tissue factor (TF) staining and scanning electron microscopy (SEM) were performed in animals with acute stent thrombosis.
Results:
Five of the 6 animals receiving an RG-13577/ATA—coated stent experienced acute stent thrombosis, while no adverse events occurred in the animals of the other 2 groups. Follow-up angiography did not show significant in-stent stenosis in either bare or ATA-coated stents. However, histomorphometry revealed larger neointimal area (3.54±0.69 mm2 versus 1.82±0.27 mm2, p |
| doi_str_mv | 10.1583/05-1641.1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_577109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1583_05-1641.1</sage_id><sourcerecordid>999573771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-453042f8ad78f29753311580b1455469c69b3c7230490164089d8a6ce9059df3</originalsourceid><addsrcrecordid>eNplkU1PAyEQhonRWL8O_gFDPJh4oMKy7C7emsaPJk002jthWVap7VKB9ePgf5dtN_bgBYZ3nrwzwwBwSvCQsIJeYYZIlpIh2QEHhKXxxRje7eIkQxlOigE49H6OcUISQvbBINIpowk_AD-P0snKfhklF_CmrrUKHtoajlpnmuCi7Er79b0wCo6UqaBsKvh0hwhleX4dpTZoOHt1dllab_w6PWnQc9BNgN25Vk0DJXyU3psPjcZWBl2tk-EY7NVy4fVJfx-B2e3NbHyPpg93k_FoihTNeUCxV5wmdSGrvKgTnjNKSRwclyRlLM24ynhJVZ5EiuM4Gy54VchMaY4Zr2p6BNDG1n_qVVuKlTNL6b6FlUb00luMtIhDEcwjf77hV86-t9oHMbeta2KHIv4fobFsB11uIOWs907Xf7YEi24tAjPRrUWQyJ71hm251NWW7PcQgYu-Q_mit9X-O_0CHVOQzA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211131459</pqid></control><display><type>article</type><title>Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Strehblow, Christoph ; Sperker, Wolfgang ; Hevesi, Akos ; Garamvölgyi, Rita ; Petrasi, Zsolt ; Shirazi, Maryam ; Sylvén, Christer ; Weiss, Thomas ; Lotan, Chaim ; Pugatsch, Thea ; Ben-Sasson, Shmuel A. ; Orlowski, Michael ; Glogar, Dietmar ; Gyöngyösi, Mariann</creator><creatorcontrib>Strehblow, Christoph ; Sperker, Wolfgang ; Hevesi, Akos ; Garamvölgyi, Rita ; Petrasi, Zsolt ; Shirazi, Maryam ; Sylvén, Christer ; Weiss, Thomas ; Lotan, Chaim ; Pugatsch, Thea ; Ben-Sasson, Shmuel A. ; Orlowski, Michael ; Glogar, Dietmar ; Gyöngyösi, Mariann</creatorcontrib><description>Purpose:
To investigate if a platelet inhibitor (aurintricarboxylic acid [ATA]) and a heparin-mimicking antagonist (RG-13577) of basic fibroblast growth factor 2 (bFGF2) could be combined as a stable compound and attached to conventional bare metal stents to hinder thrombus formation and inflammatory reactions of stenting.
Methods:
Fifteen domestic pigs were stented with RG-13577/ATA—coated (n=6), ATA-coated (n = 12), and bare metal stents (n = 12) in the left anterior descending (LAD) and left circumflex (LCX) coronary arteries. All surviving pigs were evaluated with contrast angiography and intravascular ultrasonography (IVUS) after 4 weeks. Histological analysis of the stented arteries was performed after hematoxylin-eosin staining. Tissue factor (TF) staining and scanning electron microscopy (SEM) were performed in animals with acute stent thrombosis.
Results:
Five of the 6 animals receiving an RG-13577/ATA—coated stent experienced acute stent thrombosis, while no adverse events occurred in the animals of the other 2 groups. Follow-up angiography did not show significant in-stent stenosis in either bare or ATA-coated stents. However, histomorphometry revealed larger neointimal area (3.54±0.69 mm2 versus 1.82±0.27 mm2, p<0.05) and outward plaque area (1.56±0.34 mm2 versus 0.61±0.12 mm2, p<0.05) in ATA-coated stents. Three-dimensional IVUS analysis showed analogous results, with significantly larger neointimal volume and outward plaque volume in ATA-coated stents. There was a slight increase in TF staining around the stent struts, while SEM showed increased platelet adhesion and activity in RG-13577/ATA—coated stents versus the ATA-coated and bare metal stents.
Conclusion:
RG-13577/ATA—coated stents lead to acute stent thrombosis. The ATA coating alone did not lead to acute events, but resulted in higher neointimal hyperplasia and expansive remodeling. These results underline the importance of preclinical studies before using new coated stents in human arteries.</description><identifier>ISSN: 1526-6028</identifier><identifier>EISSN: 1545-1550</identifier><identifier>DOI: 10.1583/05-1641.1</identifier><identifier>PMID: 16445329</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject><![CDATA[Animals ; Aurintricarboxylic Acid - administration & dosage ; Aurintricarboxylic Acid - pharmacology ; Aurintricarboxylic Acid - toxicity ; Coronary Angiography ; Coronary Restenosis - prevention & control ; Coronary Vessels - drug effects ; Coronary Vessels - pathology ; Drug Combinations ; Drug Evaluation, Preclinical ; Fibroblast Growth Factor 2 - antagonists & inhibitors ; Hyperplasia ; Microscopy, Electron, Scanning ; Phenoxyacetates - administration & dosage ; Phenoxyacetates - pharmacology ; Phenoxyacetates - toxicity ; Platelet Aggregation Inhibitors - administration & dosage ; Platelet Aggregation Inhibitors - pharmacology ; Platelet Aggregation Inhibitors - toxicity ; Polymers - administration & dosage ; Polymers - pharmacology ; Polymers - toxicity ; Stents - adverse effects ; Swine ; Thrombosis - diagnostic imaging ; Thrombosis - etiology ; Thrombosis - pathology ; Treatment Failure ; Tunica Intima - drug effects ; Tunica Intima - pathology]]></subject><ispartof>Journal of endovascular therapy, 2006-02, Vol.13 (1), p.94-103</ispartof><rights>2006 SAGE Publications</rights><rights>Copyright Alliance Communications Group, A Division of Allen Press, Inc. Feb 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-453042f8ad78f29753311580b1455469c69b3c7230490164089d8a6ce9059df3</citedby><cites>FETCH-LOGICAL-c379t-453042f8ad78f29753311580b1455469c69b3c7230490164089d8a6ce9059df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1583/05-1641.1$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1583/05-1641.1$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16445329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1932121$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Strehblow, Christoph</creatorcontrib><creatorcontrib>Sperker, Wolfgang</creatorcontrib><creatorcontrib>Hevesi, Akos</creatorcontrib><creatorcontrib>Garamvölgyi, Rita</creatorcontrib><creatorcontrib>Petrasi, Zsolt</creatorcontrib><creatorcontrib>Shirazi, Maryam</creatorcontrib><creatorcontrib>Sylvén, Christer</creatorcontrib><creatorcontrib>Weiss, Thomas</creatorcontrib><creatorcontrib>Lotan, Chaim</creatorcontrib><creatorcontrib>Pugatsch, Thea</creatorcontrib><creatorcontrib>Ben-Sasson, Shmuel A.</creatorcontrib><creatorcontrib>Orlowski, Michael</creatorcontrib><creatorcontrib>Glogar, Dietmar</creatorcontrib><creatorcontrib>Gyöngyösi, Mariann</creatorcontrib><title>Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent</title><title>Journal of endovascular therapy</title><addtitle>J Endovasc Ther</addtitle><description>Purpose:
To investigate if a platelet inhibitor (aurintricarboxylic acid [ATA]) and a heparin-mimicking antagonist (RG-13577) of basic fibroblast growth factor 2 (bFGF2) could be combined as a stable compound and attached to conventional bare metal stents to hinder thrombus formation and inflammatory reactions of stenting.
Methods:
Fifteen domestic pigs were stented with RG-13577/ATA—coated (n=6), ATA-coated (n = 12), and bare metal stents (n = 12) in the left anterior descending (LAD) and left circumflex (LCX) coronary arteries. All surviving pigs were evaluated with contrast angiography and intravascular ultrasonography (IVUS) after 4 weeks. Histological analysis of the stented arteries was performed after hematoxylin-eosin staining. Tissue factor (TF) staining and scanning electron microscopy (SEM) were performed in animals with acute stent thrombosis.
Results:
Five of the 6 animals receiving an RG-13577/ATA—coated stent experienced acute stent thrombosis, while no adverse events occurred in the animals of the other 2 groups. Follow-up angiography did not show significant in-stent stenosis in either bare or ATA-coated stents. However, histomorphometry revealed larger neointimal area (3.54±0.69 mm2 versus 1.82±0.27 mm2, p<0.05) and outward plaque area (1.56±0.34 mm2 versus 0.61±0.12 mm2, p<0.05) in ATA-coated stents. Three-dimensional IVUS analysis showed analogous results, with significantly larger neointimal volume and outward plaque volume in ATA-coated stents. There was a slight increase in TF staining around the stent struts, while SEM showed increased platelet adhesion and activity in RG-13577/ATA—coated stents versus the ATA-coated and bare metal stents.
Conclusion:
RG-13577/ATA—coated stents lead to acute stent thrombosis. The ATA coating alone did not lead to acute events, but resulted in higher neointimal hyperplasia and expansive remodeling. These results underline the importance of preclinical studies before using new coated stents in human arteries.</description><subject>Animals</subject><subject>Aurintricarboxylic Acid - administration & dosage</subject><subject>Aurintricarboxylic Acid - pharmacology</subject><subject>Aurintricarboxylic Acid - toxicity</subject><subject>Coronary Angiography</subject><subject>Coronary Restenosis - prevention & control</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - pathology</subject><subject>Drug Combinations</subject><subject>Drug Evaluation, Preclinical</subject><subject>Fibroblast Growth Factor 2 - antagonists & inhibitors</subject><subject>Hyperplasia</subject><subject>Microscopy, Electron, Scanning</subject><subject>Phenoxyacetates - administration & dosage</subject><subject>Phenoxyacetates - pharmacology</subject><subject>Phenoxyacetates - toxicity</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Aggregation Inhibitors - toxicity</subject><subject>Polymers - administration & dosage</subject><subject>Polymers - pharmacology</subject><subject>Polymers - toxicity</subject><subject>Stents - adverse effects</subject><subject>Swine</subject><subject>Thrombosis - diagnostic imaging</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - pathology</subject><subject>Treatment Failure</subject><subject>Tunica Intima - drug effects</subject><subject>Tunica Intima - pathology</subject><issn>1526-6028</issn><issn>1545-1550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkU1PAyEQhonRWL8O_gFDPJh4oMKy7C7emsaPJk002jthWVap7VKB9ePgf5dtN_bgBYZ3nrwzwwBwSvCQsIJeYYZIlpIh2QEHhKXxxRje7eIkQxlOigE49H6OcUISQvbBINIpowk_AD-P0snKfhklF_CmrrUKHtoajlpnmuCi7Er79b0wCo6UqaBsKvh0hwhleX4dpTZoOHt1dllab_w6PWnQc9BNgN25Vk0DJXyU3psPjcZWBl2tk-EY7NVy4fVJfx-B2e3NbHyPpg93k_FoihTNeUCxV5wmdSGrvKgTnjNKSRwclyRlLM24ynhJVZ5EiuM4Gy54VchMaY4Zr2p6BNDG1n_qVVuKlTNL6b6FlUb00luMtIhDEcwjf77hV86-t9oHMbeta2KHIv4fobFsB11uIOWs907Xf7YEi24tAjPRrUWQyJ71hm251NWW7PcQgYu-Q_mit9X-O_0CHVOQzA</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Strehblow, Christoph</creator><creator>Sperker, Wolfgang</creator><creator>Hevesi, Akos</creator><creator>Garamvölgyi, Rita</creator><creator>Petrasi, Zsolt</creator><creator>Shirazi, Maryam</creator><creator>Sylvén, Christer</creator><creator>Weiss, Thomas</creator><creator>Lotan, Chaim</creator><creator>Pugatsch, Thea</creator><creator>Ben-Sasson, Shmuel A.</creator><creator>Orlowski, Michael</creator><creator>Glogar, Dietmar</creator><creator>Gyöngyösi, Mariann</creator><general>SAGE Publications</general><general>Allen Press Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20060201</creationdate><title>Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent</title><author>Strehblow, Christoph ; Sperker, Wolfgang ; Hevesi, Akos ; Garamvölgyi, Rita ; Petrasi, Zsolt ; Shirazi, Maryam ; Sylvén, Christer ; Weiss, Thomas ; Lotan, Chaim ; Pugatsch, Thea ; Ben-Sasson, Shmuel A. ; Orlowski, Michael ; Glogar, Dietmar ; Gyöngyösi, Mariann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-453042f8ad78f29753311580b1455469c69b3c7230490164089d8a6ce9059df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Aurintricarboxylic Acid - administration & dosage</topic><topic>Aurintricarboxylic Acid - pharmacology</topic><topic>Aurintricarboxylic Acid - toxicity</topic><topic>Coronary Angiography</topic><topic>Coronary Restenosis - prevention & control</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - pathology</topic><topic>Drug Combinations</topic><topic>Drug Evaluation, Preclinical</topic><topic>Fibroblast Growth Factor 2 - antagonists & inhibitors</topic><topic>Hyperplasia</topic><topic>Microscopy, Electron, Scanning</topic><topic>Phenoxyacetates - administration & dosage</topic><topic>Phenoxyacetates - pharmacology</topic><topic>Phenoxyacetates - toxicity</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet Aggregation Inhibitors - toxicity</topic><topic>Polymers - administration & dosage</topic><topic>Polymers - pharmacology</topic><topic>Polymers - toxicity</topic><topic>Stents - adverse effects</topic><topic>Swine</topic><topic>Thrombosis - diagnostic imaging</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - pathology</topic><topic>Treatment Failure</topic><topic>Tunica Intima - drug effects</topic><topic>Tunica Intima - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strehblow, Christoph</creatorcontrib><creatorcontrib>Sperker, Wolfgang</creatorcontrib><creatorcontrib>Hevesi, Akos</creatorcontrib><creatorcontrib>Garamvölgyi, Rita</creatorcontrib><creatorcontrib>Petrasi, Zsolt</creatorcontrib><creatorcontrib>Shirazi, Maryam</creatorcontrib><creatorcontrib>Sylvén, Christer</creatorcontrib><creatorcontrib>Weiss, Thomas</creatorcontrib><creatorcontrib>Lotan, Chaim</creatorcontrib><creatorcontrib>Pugatsch, Thea</creatorcontrib><creatorcontrib>Ben-Sasson, Shmuel A.</creatorcontrib><creatorcontrib>Orlowski, Michael</creatorcontrib><creatorcontrib>Glogar, Dietmar</creatorcontrib><creatorcontrib>Gyöngyösi, Mariann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of endovascular therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strehblow, Christoph</au><au>Sperker, Wolfgang</au><au>Hevesi, Akos</au><au>Garamvölgyi, Rita</au><au>Petrasi, Zsolt</au><au>Shirazi, Maryam</au><au>Sylvén, Christer</au><au>Weiss, Thomas</au><au>Lotan, Chaim</au><au>Pugatsch, Thea</au><au>Ben-Sasson, Shmuel A.</au><au>Orlowski, Michael</au><au>Glogar, Dietmar</au><au>Gyöngyösi, Mariann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent</atitle><jtitle>Journal of endovascular therapy</jtitle><addtitle>J Endovasc Ther</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>13</volume><issue>1</issue><spage>94</spage><epage>103</epage><pages>94-103</pages><issn>1526-6028</issn><eissn>1545-1550</eissn><abstract>Purpose:
To investigate if a platelet inhibitor (aurintricarboxylic acid [ATA]) and a heparin-mimicking antagonist (RG-13577) of basic fibroblast growth factor 2 (bFGF2) could be combined as a stable compound and attached to conventional bare metal stents to hinder thrombus formation and inflammatory reactions of stenting.
Methods:
Fifteen domestic pigs were stented with RG-13577/ATA—coated (n=6), ATA-coated (n = 12), and bare metal stents (n = 12) in the left anterior descending (LAD) and left circumflex (LCX) coronary arteries. All surviving pigs were evaluated with contrast angiography and intravascular ultrasonography (IVUS) after 4 weeks. Histological analysis of the stented arteries was performed after hematoxylin-eosin staining. Tissue factor (TF) staining and scanning electron microscopy (SEM) were performed in animals with acute stent thrombosis.
Results:
Five of the 6 animals receiving an RG-13577/ATA—coated stent experienced acute stent thrombosis, while no adverse events occurred in the animals of the other 2 groups. Follow-up angiography did not show significant in-stent stenosis in either bare or ATA-coated stents. However, histomorphometry revealed larger neointimal area (3.54±0.69 mm2 versus 1.82±0.27 mm2, p<0.05) and outward plaque area (1.56±0.34 mm2 versus 0.61±0.12 mm2, p<0.05) in ATA-coated stents. Three-dimensional IVUS analysis showed analogous results, with significantly larger neointimal volume and outward plaque volume in ATA-coated stents. There was a slight increase in TF staining around the stent struts, while SEM showed increased platelet adhesion and activity in RG-13577/ATA—coated stents versus the ATA-coated and bare metal stents.
Conclusion:
RG-13577/ATA—coated stents lead to acute stent thrombosis. The ATA coating alone did not lead to acute events, but resulted in higher neointimal hyperplasia and expansive remodeling. These results underline the importance of preclinical studies before using new coated stents in human arteries.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>16445329</pmid><doi>10.1583/05-1641.1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1526-6028 |
| ispartof | Journal of endovascular therapy, 2006-02, Vol.13 (1), p.94-103 |
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| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Animals Aurintricarboxylic Acid - administration & dosage Aurintricarboxylic Acid - pharmacology Aurintricarboxylic Acid - toxicity Coronary Angiography Coronary Restenosis - prevention & control Coronary Vessels - drug effects Coronary Vessels - pathology Drug Combinations Drug Evaluation, Preclinical Fibroblast Growth Factor 2 - antagonists & inhibitors Hyperplasia Microscopy, Electron, Scanning Phenoxyacetates - administration & dosage Phenoxyacetates - pharmacology Phenoxyacetates - toxicity Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - toxicity Polymers - administration & dosage Polymers - pharmacology Polymers - toxicity Stents - adverse effects Swine Thrombosis - diagnostic imaging Thrombosis - etiology Thrombosis - pathology Treatment Failure Tunica Intima - drug effects Tunica Intima - pathology |
| title | Paradoxical Effects of Aurintricarboxylic Acid and RG-13577: Acute Thrombosis and In-Stent Stenosis in a Passive-Coated Stent |
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