LRRK2 expression linked to dopamine-innervated areas

Objective Leucine‐rich repeat kinase 2 (LRRK2) has been linked to Parkinson's disease. Our study explores the expression of LRRK2 in human and rodent brain tissue. Methods We analyzed LRRK2 gene activity at the cellular level using in situ hybridization. Results We found a high and strikingly s...

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Veröffentlicht in:	Annals of neurology 2006-04, Vol.59 (4), p.714-719
Hauptverfasser:	Galter, Dagmar, Westerlund, Marie, Carmine, Andrea, Lindqvist, Eva, Sydow, Olof, Olson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Biological and medical sciences Brain - anatomy & histology Brain - metabolism Case-Control Studies Dopamine - metabolism Drug toxicity and drugs side effects treatment Female Gene Expression - physiology Humans In Situ Hybridization - methods Injuries of the nervous system and the skull. Diseases due to physical agents Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medical sciences Mice Mice, Inbred C57BL Middle Aged Neurology Parkinson Disease - genetics Parkinson Disease - metabolism Pharmacology. Drug treatments Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Toxicity: nervous system and muscle Traumas. Diseases due to physical agents
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