Cartilage aggrecan undergoes significant compositional and structural alterations during laryngeal cancer

Aggrecan is a key component of cartilage and is responsible for the integrity and function of the tissue. In this study, the content of aggrecan and its structural modifications in adjacent to cancer apparently normal cartilages (AANCs) from various stages of laryngeal squamous cell carcinoma (LSCC)...

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Veröffentlicht in:	Biochimica et biophysica acta 2006-07, Vol.1760 (7), p.1046-1053
Hauptverfasser:	Skandalis, Spyros S., Theocharis, Achilleas D., Vynios, Demitrios H., Papageorgakopoulou, Nickoletta, Hjerpe, Anders, Karamanos, Nikos K., Theocharis, Dimitrios A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aggrecan degradation Aggrecans Aggregable aggrecan Carcinoma, Squamous Cell - metabolism Cartilage Cartilage - metabolism Cartilage - pathology Chondroitin Sulfate Proteoglycans - biosynthesis Chondroitin Sulfate Proteoglycans - chemistry Extracellular Matrix Proteins - biosynthesis Extracellular Matrix Proteins - chemistry Gene Expression Regulation, Neoplastic Glycosaminoglycans - chemistry Humans Immunohistochemistry Laryngeal cancer Laryngeal Neoplasms - metabolism Lectins, C-Type - biosynthesis Lectins, C-Type - chemistry Male Middle Aged Peptides - chemistry Protein Binding Protein Structure, Tertiary Proteoglycans
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