Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer

The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tu...

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Veröffentlicht in:British journal of cancer 2006-06, Vol.94 (11), p.1683-1689
Hauptverfasser: Beskow, C, Kanter, L, Holgersson, Å, Nilsson, B, Frankendal, B, Åvall-Lundqvist, E, Lewensohn, R
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container_end_page 1689
container_issue 11
container_start_page 1683
container_title British journal of cancer
container_volume 94
creator Beskow, C
Kanter, L
Holgersson, Å
Nilsson, B
Frankendal, B
Åvall-Lundqvist, E
Lewensohn, R
description The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from 109 patients with cervical cancer, FIGO-stage IB–IIA, treated with preoperative brachytherapy followed by radical surgery were analysed by immunohistochemistry. In addition, correlation studies between early pathological tumour response to radiation and expression of Ku86, Ku70, Mdm-2, p53 and p21 in primary tumours were also performed. We found that tumour-transformed tissue shows positive immunostaining of DNA-PKcs, Ku86 and Ku70, while non-neoplastic squamous epithelium and tumour-free cervix glands show negative immunoreactivity. Expression of DNA-PKcs positively correlated with both Ku86 and Ku70, and a statistically significant correlation between the Ku subunits was also found. After RT, 85 patients demonstrated pathologic complete remission (pCR), whereas 24 patients had residual tumour in the surgical specimen (non-pCR). The main finding of our study is that there was no correlation between the outcome of RT and the expression of DNA-PK subunits. Positive p53 tumours were significantly more common among non-pCR cases than in patients with pCR ( P =0.031). Expression of p21 and Mdm-2 did not correlate with the outcome of RT.
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subjects Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cervical cancer
DNA Damage
DNA Repair - genetics
DNA, Neoplasm - genetics
Drug Resistance
Epidemiology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Medical sciences
Medicin och hälsovetenskap
Molecular Diagnostics
Molecular Medicine
Neoplasm Proteins - genetics
Neoplasm Staging
Oncology
Treatment Outcome
Tumors
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - radiotherapy
title Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer
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