DRB10401-Restricted Human T Cell Clone Specific for the Major Proinsulin73-90 Epitope Expresses a Down-Regulatory T Helper 2 Phenotype

Recently, we have identified proinsulin $(P-Ins)_{73-90}$ as an immunodominant T cell epitope of HLA-DRB1*0401 (DR4) subjects with β-islet cell autoimmunity and of HLA-DR4/CD4 double-transgenic mice immunized with human P-Ins. We have compared the fine specificities of one human CD4 T cell clone and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-08, Vol.103 (31), p.11683-11688
Hauptverfasser:	Durinovic-Belló, Ivana, Rosinger, Silke, Olson, Jennifer A., Congia, Mauro, Ahmad, Regina C., Rickert, Mathias, Hampl, Johannes, Kalbacher, Hubert, Drijfhout, Jan W., Mellins, Elizabeth D., Al Dahouk, Sascha, Kamradt, Thomas, Maeurer, Markus J., Nhan, Carol, Roep, Bart O., Boehm, Bernhard O., Polychronakos, Constantin, Nepom, Gerald T., Karges, Wolfram, McDevitt, Hugh O., Sønderstrup, Grete
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Amino Acids - metabolism Animals Antigens Biological Sciences Cell lines Cells Cloning Cytokines Diabetes Epitopes Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Genotype & phenotype HLA-DR Antigens - immunology HLA-DRB1 Chains Humans Hybridomas Immunology Insulin Mice Mice, Transgenic Molecular Sequence Data Peptide Fragments - metabolism Phenotype Proinsulin - metabolism Reactivity T cell antigen receptors T lymphocytes T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology Type 1 diabetes mellitus
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