A 28-Day Oral Dose Toxicity Study Enhanced to Detect Endocrine Effects of Hexabromocyclododecane in Wistar Rats

A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily gavage to HBCD dissolved in corn oil in 8 dose groups with doses ranging between 0 and 200 mg/kg bw per day (mkd). Evaluation consi...

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Veröffentlicht in:	Toxicological sciences 2006-12, Vol.94 (2), p.281-292
Hauptverfasser:	van der Ven, Leo T. M., Verhoef, Aart, van de Kuil, Ton, Slob, Wout, Leonards, Pim E. G., Visser, Theo J., Hamers, Timo, Herlin, Maria, Håkansson, Helen, Olausson, Hanna, Piersma, Aldert H., Vos, Josephus G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Bone Density - drug effects brominated flame retardants Cell Count Dose-Response Relationship, Drug endocrine disruption Endocrine Disruptors - classification Endocrine Disruptors - toxicity Female Glucuronosyltransferase - biosynthesis hazard identification hexabromocyclododecane Hydrocarbons, Brominated - classification Hydrocarbons, Brominated - toxicity Liver - drug effects Liver - pathology Male Medicin och hälsovetenskap Organ Size - drug effects Pituitary Gland - drug effects Pituitary Gland - metabolism Pituitary Gland - pathology Rats Rats, Wistar Risk Assessment Spleen - drug effects Spleen - pathology Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Gland - pathology thyroid hormones Thyrotropin - metabolism Tibia - drug effects Tibia - metabolism Toxicity Tests
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