Mitochondrial oxidative stress : Implications for cell death

In addition to the established role of the mitochondria in energy metabolism, regulation of cell death has emerged as a second major function of these organelles. This seems to be intimately linked to their generation of reactive oxygen species (ROS), which have been implicated in mtDNA mutations, a...

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Veröffentlicht in:	Annual review of pharmacology and toxicology 2007-01, Vol.47 (1), p.143-183
Hauptverfasser:	ORRENIUS, Sten, GOGVADZE, Vladimir, ZHIVOTOVSKY, Boris
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Apoptosis - physiology Biological and medical sciences Cardiolipins - physiology Cell physiology Fundamental and applied biological sciences. Psychology Medicin och hälsovetenskap Mitochondria - physiology Molecular and cellular biology Necrosis Oxidative Stress - physiology Reactive Oxygen Species
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