Changes in brain cholinergic markers and spatial learning in old galanin-overexpressing mice

Abstract The cholinergic forebrain system is involved in learning and memory, and its age-dependent decline correlates with a decrease in cognitive performance. Since the neuropeptide galanin participates in cholinergic neuron regulation, we have studied 19- to 23-month-old male mice overexpressing...

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Veröffentlicht in:	Brain research 2007-03, Vol.1138, p.10-20
Hauptverfasser:	Pirondi, S, D’Intino, G, Gusciglio, M, Massella, A, Giardino, L, Kuteeva, E, Ögren, S.-O, Hökfelt, T, Calzà, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Aging - psychology Animals Behavior Biological and medical sciences Biomarkers - metabolism Brain - metabolism Brain-Derived Neurotrophic Factor - genetics Cerebral Cortex - enzymology Choline O-Acetyltransferase - metabolism Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Galanin Galanin - genetics Galanin - metabolism Hippocampus - enzymology Hippocampus - metabolism Immunohistochemistry Male Maze Learning - physiology Mice Mice, Transgenic Motor Activity - physiology Nerve Growth Factors - genetics Neurology Prosencephalon - cytology Prosencephalon - enzymology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Stress Swimming Transgenic mice Vertebrates: nervous system and sense organs Water maze
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