Improved outcome from substituting methotrexate with epirubicin: Results from a randomised comparison of CMF versus CEF in patients with primary breast cancer

Abstract We compared the efficacy of CEF (cyclophosphamide, epirubicin, and fluorouracil) against CMF (cyclophosphamide, methotrexate, and fluorouracil) in moderate or high risk breast cancer patients. We randomly assigned 1224 patients with completely resected unilateral breast cancer to receive ni...

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Veröffentlicht in:	European journal of cancer (1990) 2007-03, Vol.43 (5), p.877-884
Hauptverfasser:	Ejlertsen, Bent, Mouridsen, Henning T, Jensen, Maj-Britt, Andersen, Jørn, Cold, Søren, Edlund, Per, Ewertz, Marianne, Jensen, Brita B, Kamby, Claus, Nordenskjold, Bo, Bergh, Jonas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic combined chemotherapy protocols Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastic Combined Chemotherapy Protocols/administration & dosage/therapeutic use Biological and medical sciences Breast neoplasms Breast Neoplasms - drug therapy Cyclophosphamide Cyclophosphamide - administration & dosage Cytarabine - administration & dosage Epirubicin Epirubicin - administration & dosage Female Fluorouracil Fluorouracil - administration & dosage Hematology, Oncology and Palliative Medicine Humans Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Methotrexate Methotrexate - administration & dosage Middle Aged Pharmacology. Drug treatments Proportional hazards models Randomised controlled trials Survival analysis Treatment Outcome Tumors
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