Vaccination of horses against strangles using recombinant antigens from Streptococcus equi
Abstract Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi , the causative agent for str...
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| Veröffentlicht in: | Vaccine 2007-05, Vol.25 (18), p.3629-3635 |
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| container_title | Vaccine |
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| creator | Waller, Andrew Flock, Margareta Smith, Ken Robinson, Carl Mitchell, Zoe Karlström, Åsa Lannergård, Jonas Bergman, Rune Guss, Bengt Flock, Jan-Ingmar |
| description | Abstract Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi , the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth ( p = 0.02) and nasal discharge ( p = 0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group ( p = 0.01). The antigens used were EAG (α2 -macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant. |
| doi_str_mv | 10.1016/j.vaccine.2007.01.060 |
| format | Article |
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Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi , the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth ( p = 0.02) and nasal discharge ( p = 0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group ( p = 0.01). The antigens used were EAG (α2 -macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2007.01.060</identifier><identifier>PMID: 17321016</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Antigens, Bacterial - genetics ; Antigens, Bacterial - immunology ; Applied microbiology ; Bacteriology ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Fundamental and applied biological sciences. Psychology ; Horse Diseases - microbiology ; Horse Diseases - prevention & control ; Horses ; Immunoglobulin G - blood ; Medicin och hälsovetenskap ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; Microbiology ; Miscellaneous ; Recombinant Proteins - genetics ; Recombinant Proteins - immunology ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - prevention & control ; Respiratory Tract Infections - veterinary ; Streptococcal Infections - microbiology ; Streptococcal Infections - prevention & control ; Streptococcal Infections - veterinary ; Streptococcal Vaccines - administration & dosage ; Streptococcal Vaccines - genetics ; Streptococcal Vaccines - immunology ; Streptococcus equi ; Streptococcus equi - genetics ; Streptococcus equi - immunology ; Streptococcus equi - pathogenicity ; Surface proteins ; Vaccination ; Vaccination - veterinary ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2007-05, Vol.25 (18), p.3629-3635</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-71615a1e9aa165ee77ed0183f7909f2b6a27dfb559ac8941f9dea055ccc83a643</citedby><cites>FETCH-LOGICAL-c567t-71615a1e9aa165ee77ed0183f7909f2b6a27dfb559ac8941f9dea055ccc83a643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vaccine.2007.01.060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64387</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18701469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17321016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:115478448$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Waller, Andrew</creatorcontrib><creatorcontrib>Flock, Margareta</creatorcontrib><creatorcontrib>Smith, Ken</creatorcontrib><creatorcontrib>Robinson, Carl</creatorcontrib><creatorcontrib>Mitchell, Zoe</creatorcontrib><creatorcontrib>Karlström, Åsa</creatorcontrib><creatorcontrib>Lannergård, Jonas</creatorcontrib><creatorcontrib>Bergman, Rune</creatorcontrib><creatorcontrib>Guss, Bengt</creatorcontrib><creatorcontrib>Flock, Jan-Ingmar</creatorcontrib><title>Vaccination of horses against strangles using recombinant antigens from Streptococcus equi</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi , the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth ( p = 0.02) and nasal discharge ( p = 0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group ( p = 0.01). The antigens used were EAG (α2 -macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens, Bacterial - genetics</subject><subject>Antigens, Bacterial - immunology</subject><subject>Applied microbiology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Horse Diseases - microbiology</subject><subject>Horse Diseases - prevention & control</subject><subject>Horses</subject><subject>Immunoglobulin G - blood</subject><subject>Medicin och hälsovetenskap</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - immunology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - immunology</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Respiratory Tract Infections - veterinary</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - prevention & control</subject><subject>Streptococcal Infections - veterinary</subject><subject>Streptococcal Vaccines - administration & dosage</subject><subject>Streptococcal Vaccines - genetics</subject><subject>Streptococcal Vaccines - immunology</subject><subject>Streptococcus equi</subject><subject>Streptococcus equi - genetics</subject><subject>Streptococcus equi - immunology</subject><subject>Streptococcus equi - pathogenicity</subject><subject>Surface proteins</subject><subject>Vaccination</subject><subject>Vaccination - veterinary</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAUhYso7uzqT1D6om8d722TJn1RZHFVWPBhVcSXkElvx8x2ktmkXdl_b2qrA4LsQ0gI3zn3wjlZ9gxhjYD1q936VhtjHa1LALEGXEMND7IVSlEVJUf5MFtBWbOCIXw7yU5j3AEAr7B5nJ2gqMrJZZV9__rbRQ_Wu9x3-Q8fIsVcb7V1ccjjELTb9ulnjNZt80DG7zeJd0Oejt2Si3kX_D6_GgIdBm-8MWPM6Wa0T7JHne4jPV3us-zLxbvP5x-Ky0_vP56_vSwMr8VQCKyRa6RGa6w5kRDUAsqqEw00XbmpdSnabsN5o41sGHZNSxo4N8bIStesOsuK2Tf-pMO4UYdg9zrcKa-tWr6u04sUF8iYTHzzX_4QfHsU_REicibkrH05axN4M1Ic1N5GQ32vHfkxKgEMmJTNvWAJpQTGqwTyGTTBxxio-7sPgpoyUju1JK2mpBWgSkkn3fNlwLjZU3tULdEm4MUC6Gh036UgjY1HTgpAVk-bvpk5ShndWgoqGkvOUGtT2oNqvb13ldf_OJjeOpuGXtMdxZ0fg0sFUKhiqUBdTbWcWgkiNbIBVv0COGXhGA</recordid><startdate>20070504</startdate><enddate>20070504</enddate><creator>Waller, Andrew</creator><creator>Flock, Margareta</creator><creator>Smith, Ken</creator><creator>Robinson, Carl</creator><creator>Mitchell, Zoe</creator><creator>Karlström, Åsa</creator><creator>Lannergård, Jonas</creator><creator>Bergman, Rune</creator><creator>Guss, Bengt</creator><creator>Flock, Jan-Ingmar</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20070504</creationdate><title>Vaccination of horses against strangles using recombinant antigens from Streptococcus equi</title><author>Waller, Andrew ; Flock, Margareta ; Smith, Ken ; Robinson, Carl ; Mitchell, Zoe ; Karlström, Åsa ; Lannergård, Jonas ; Bergman, Rune ; Guss, Bengt ; Flock, Jan-Ingmar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-71615a1e9aa165ee77ed0183f7909f2b6a27dfb559ac8941f9dea055ccc83a643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigens, Bacterial - genetics</topic><topic>Antigens, Bacterial - immunology</topic><topic>Applied microbiology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Horse Diseases - microbiology</topic><topic>Horse Diseases - prevention & control</topic><topic>Horses</topic><topic>Immunoglobulin G - blood</topic><topic>Medicin och hälsovetenskap</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - immunology</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - immunology</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Respiratory Tract Infections - veterinary</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcal Infections - prevention & control</topic><topic>Streptococcal Infections - veterinary</topic><topic>Streptococcal Vaccines - administration & dosage</topic><topic>Streptococcal Vaccines - genetics</topic><topic>Streptococcal Vaccines - immunology</topic><topic>Streptococcus equi</topic><topic>Streptococcus equi - genetics</topic><topic>Streptococcus equi - immunology</topic><topic>Streptococcus equi - pathogenicity</topic><topic>Surface proteins</topic><topic>Vaccination</topic><topic>Vaccination - veterinary</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Waller, Andrew</creatorcontrib><creatorcontrib>Flock, Margareta</creatorcontrib><creatorcontrib>Smith, Ken</creatorcontrib><creatorcontrib>Robinson, Carl</creatorcontrib><creatorcontrib>Mitchell, Zoe</creatorcontrib><creatorcontrib>Karlström, Åsa</creatorcontrib><creatorcontrib>Lannergård, Jonas</creatorcontrib><creatorcontrib>Bergman, Rune</creatorcontrib><creatorcontrib>Guss, Bengt</creatorcontrib><creatorcontrib>Flock, Jan-Ingmar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waller, Andrew</au><au>Flock, Margareta</au><au>Smith, Ken</au><au>Robinson, Carl</au><au>Mitchell, Zoe</au><au>Karlström, Åsa</au><au>Lannergård, Jonas</au><au>Bergman, Rune</au><au>Guss, Bengt</au><au>Flock, Jan-Ingmar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination of horses against strangles using recombinant antigens from Streptococcus equi</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2007-05-04</date><risdate>2007</risdate><volume>25</volume><issue>18</issue><spage>3629</spage><epage>3635</epage><pages>3629-3635</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi , the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth ( p = 0.02) and nasal discharge ( p = 0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group ( p = 0.01). The antigens used were EAG (α2 -macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17321016</pmid><doi>10.1016/j.vaccine.2007.01.060</doi><tpages>7</tpages></addata></record> |
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| ispartof | Vaccine, 2007-05, Vol.25 (18), p.3629-3635 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Allergy and Immunology Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacteriology Biological and medical sciences Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Horse Diseases - microbiology Horse Diseases - prevention & control Horses Immunoglobulin G - blood Medicin och hälsovetenskap Membrane Proteins - genetics Membrane Proteins - immunology Microbiology Miscellaneous Recombinant Proteins - genetics Recombinant Proteins - immunology Respiratory Tract Infections - microbiology Respiratory Tract Infections - prevention & control Respiratory Tract Infections - veterinary Streptococcal Infections - microbiology Streptococcal Infections - prevention & control Streptococcal Infections - veterinary Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus equi Streptococcus equi - genetics Streptococcus equi - immunology Streptococcus equi - pathogenicity Surface proteins Vaccination Vaccination - veterinary Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Vaccination of horses against strangles using recombinant antigens from Streptococcus equi |
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