Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia

A 10-year-old girl with steroid-resistent Diamond-Blackfan anemia (DBA) developed agranulocytosis 9 weeks after chelation with deferiprone was initiated (45 mg/kg daily, 60% of recommended dose) in addition to her ordinary deferoxamine therapy. The blood counts, checked weekly, dropped markedly betw...

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Veröffentlicht in:	Blood 2007-06, Vol.109 (12), p.5157-5159
Hauptverfasser:	Henter, Jan-Inge, Karlén, Jonas
Format:	Artikel
Sprache:	eng
Schlagworte:	Agranulocytosis - chemically induced Anemia, Diamond-Blackfan - complications Anemia, Diamond-Blackfan - drug therapy Anemias. Hemoglobinopathies Biological and medical sciences Blood Cell Count Bone Marrow - pathology Child Contraindications Deferiprone Diseases of red blood cells Fatal Outcome Female Hematologic and hematopoietic diseases Humans Medical sciences Other diseases. Hematologic involvement in other diseases Pyridones - adverse effects Pyridones - therapeutic use Thalassemia - complications
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