Coxsackievirus B3 and adenovirus infections of cardiac cells are efficiently inhibited by vector-mediated RNA interference targeting their common receptor

As coxsackievirus B3 (CoxB3) and adenoviruses may cause acute myocarditis and inflammatory cardiomyopathy, isolation of the common coxsackievirus-adenovirus-receptor (CAR) has provided an interesting new target for molecular antiviral therapy. Whereas many viruses show high mutation rates enabling t...

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Veröffentlicht in:	Gene therapy 2007-06, Vol.14 (12), p.960-971
Hauptverfasser:	FECHNER, H, PINKERT, S, VETTER, R, SCHULTHEISS, H.-P, POLLER, W, WANG, X, SIPO, I, SUCKAU, L, KURRECK, J, DÖRNER, A, SOLLERBRANT, K, ZEICHHARDT, H, GRUNERT, H.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenoviridae Infections - therapy Adenovirus Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antiviral agents Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Cardiomyocytes Cardiomyopathy Cardiovascular disease Care and treatment Cell Line Cell receptors Cell structures and functions Cells, Cultured Coxsackie and Adenovirus Receptor-Like Membrane Protein Coxsackievirus B3 Coxsackievirus Infections - therapy Coxsackieviruses Enterovirus B, Human Expression vectors Fundamental and applied biological sciences. Psychology Gene expression Gene Silencing Gene therapy Genetic aspects Genetic Engineering Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Health. Pharmaceutical industry Heart diseases Industrial applications and implications. Economical aspects Inflammation Medical sciences Medicin och hälsovetenskap Miscellaneous Molecular and cellular biology Mutation Mutation rates Myocarditis Myocarditis - therapy Myocarditis - virology Myocytes, Cardiac - virology Neonates Rats Receptors Receptors, Virus - genetics Ribonucleic acid RNA RNA Interference RNA, Small Interfering - administration & dosage RNA-mediated interference Transfusions. Complications. Transfusion reactions. Cell and gene therapy Virus Replication - genetics Viruses
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