Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis

Gene-gene and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex diseases. The aim of this study was to use and compare three different definitions of interaction between the two major genetic risk factors of RA—the HLA-DRB1 shared epitop...

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Veröffentlicht in:	American journal of human genetics 2007-05, Vol.80 (5), p.867-875
Hauptverfasser:	Källberg, Henrik, Padyukov, Leonid, Plenge, Robert M., Rönnelid, Johan, Gregersen, Peter K., van der Helm-van Mil, Annette H.M., Toes, Rene E.M., Huizinga, Tom W., Klareskog, Lars, Alfredsson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Arthritis, Rheumatoid - classification Arthritis, Rheumatoid - etiology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - blood Biological and medical sciences Case-Control Studies Comparative analysis Female Fundamental and applied biological sciences. Psychology General aspects. Genetic counseling Genes Genetic linkage Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genotype HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Linkage Disequilibrium Male Medical genetics Medical sciences MEDICIN MEDICINE Middle Aged Molecular and cellular biology Peptides, Cyclic - immunology Phenotype Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases - genetics Rheumatoid arthritis Risk Factors Smoking Smoking - adverse effects Studies Tobacco, tobacco smoking Toxicology
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