Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa

Despite the pharmacodynamic advantages with artemisinin-based combination therapy (ACT) and some potentially opposite molecular mechanisms of tolerance to amodiaquine (AQ)/desethylamodiaquine (DEAQ) and artesunate (ART), there is a risk for rapid decay in efficacy if the two drugs are unable to ensu...

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Veröffentlicht in:	Infection, genetics and evolution genetics and evolution, 2007-09, Vol.7 (5), p.562-569
Hauptverfasser:	Holmgren, Gabrielle, Hamrin, Johan, Svärd, Jenny, Mårtensson, Andreas, Gil, José Pedro, Björkman, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	ACT Amodiaquine Amodiaquine - administration & dosage Amodiaquine - pharmacology Amodiaquine - therapeutic use Animals Artemisinins - administration & dosage Artemisinins - pharmacology Artemisinins - therapeutic use Child, Preschool Clinical Trials as Topic Desethylamodiaquine Humans Kenya Malaria Medicin och hälsovetenskap Membrane Transport Proteins - genetics Multidrug Resistance-Associated Proteins - genetics Odds Ratio pfcrt pfmdr1 Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Protozoan Proteins - genetics Resistance Selection, Genetic Tanzania Zanzibar
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