Intra- and extracellular signaling by endothelial neuregulin-1

Suppression of tumor growth by inhibition of ErbB receptor signaling is well documented. However, relatively little is known about the ErbB signaling system in the regulation of angiogenesis, a process necessary for tumor growth. We have previously shown that heparin-binding EGF-like growth factor (...

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Veröffentlicht in:	Experimental cell research 2007-08, Vol.313 (13), p.2896-2909
Hauptverfasser:	Iivanainen, Erika, Paatero, Ilkka, Heikkinen, Satu-Maria, Junttila, Teemu T., Cao, Renhai, Klint, Peter, Jaakkola, Panu M., Cao, Yihai, Elenius, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenic Proteins - metabolism Angiogenic Proteins - pharmacology Cell Hypoxia Cell Movement Cellular biology Endothelial cell Endothelium, Vascular - chemistry Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Epidermal growth factor Epidermal Growth Factor - metabolism ErbB gamma-secretase Heparin-binding EGF-like Growth Factor Humans Intercellular Signaling Peptides and Proteins MEDICIN MEDICINE Molecular biology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Neovascularization, Physiologic Neuregulin-1 - genetics Neuregulin-1 - metabolism Neuregulin-1 - pharmacology Paracrine Communication Receptor Protein-Tyrosine Kinases - analysis Receptor Protein-Tyrosine Kinases - metabolism Recombinant Proteins - genetics Recombinant Proteins - pharmacology Signal Transduction Tumors Umbilical Cord - cytology Up-Regulation Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular Endothelial Growth Factors - metabolism γ-Secretase
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