Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer

Familial clustering studies indicate that breast cancer risk has a substantial genetic component 1 , 2 , 3 . To identify new breast cancer risk variants, we genotyped approximately 300,000 SNPs in 1,600 Icelandic individuals with breast cancer and 11,563 controls using the Illumina Hap300 platform....

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Veröffentlicht in:	Nature genetics 2007-07, Vol.39 (7), p.865-869
Hauptverfasser:	Stacey, Simon N, Manolescu, Andrei, Sulem, Patrick, Rafnar, Thorunn, Gudmundsson, Julius, Gudjonsson, Sigurjon A, Masson, Gisli, Jakobsdottir, Margret, Thorlacius, Steinunn, Helgason, Agnar, Aben, Katja K, Strobbe, Luc J, Albers-Akkers, Marjo T, Swinkels, Dorine W, Henderson, Brian E, Kolonel, Laurence N, Le Marchand, Loic, Millastre, Esther, Andres, Raquel, Godino, Javier, Garcia-Prats, Maria Dolores, Polo, Eduardo, Tres, Alejandro, Mouy, Magali, Saemundsdottir, Jona, Backman, Valgerdur M, Gudmundsson, Larus, Kristjansson, Kristleifur, Bergthorsson, Jon T, Kostic, Jelena, Frigge, Michael L, Geller, Frank, Gudbjartsson, Daniel, Sigurdsson, Helgi, Jonsdottir, Thora, Hrafnkelsson, Jon, Johannsson, Jakob, Sveinsson, Thorarinn, Myrdal, Gardar, Grimsson, Hlynur Niels, Jonsson, Thorvaldur, von Holst, Susanna, Werelius, Barbro, Margolin, Sara, Lindblom, Annika, Mayordomo, Jose I, Haiman, Christopher A, Kiemeney, Lambertus A, Johannsson, Oskar Th, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Research Case-Control Studies Chromosomes Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Pair 2 - genetics Classical genetics, quantitative genetics, hybrids Diagnosis Estrogen Estrogens Female Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype & phenotype Gynecology. Andrology. Obstetrics Health risks Human Genetics Humans letter Mammary gland diseases Medical sciences Methods, theories and miscellaneous Physiological aspects Receptors Receptors, Estrogen - biosynthesis Risk factors Single nucleotide polymorphisms Tumors
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