Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration

Mutations in PINK1 cause the mitochondrial-related neurodegenerative disease Parkinson's. Here we investigate whether obesity, type 2 diabetes, or inactivity alters transcription from the PINK1 locus. We utilized a cDNA-array and quantitative real-time PCR for gene expression analysis of muscle...

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Veröffentlicht in:	The FASEB journal 2007-11, Vol.21 (13), p.3653-3665
Hauptverfasser:	Scheele, Camilla, Nielsen, Anders Rinnov, Walden, Tomas B, Sewell, Dean A, Fischer, Christian P, Brogan, Robert J, Petrovic, Natasa, Larsson, Ola, Tesch, Per A, Wennmalm, Kristian, Hutchinson, Dana S, Cannon, Barbara, Wahlestedt, Claes, Pedersen, Bente K, Timmons, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult altered gene regulation Cohort Studies Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Female gene expression Humans Idrott Idrottsvetenskap inactivity INTERDISCIPLINARY RESEARCH AREAS Male metabolism Middle Aged mitochondria muscle disuse Neurodegenerative Diseases - complications Neurodegenerative Diseases - genetics Protein Kinases - genetics Sports TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN unloading
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