PIK3CA Mutations and PTEN Loss Correlate with Similar Prognostic Factors and Are Not Mutually Exclusive in Breast Cancer

Purpose: The phosphatidylinositol 3′-kinase/Akt pathway is frequently altered in breast cancer. PTEN, a phosphatase that opposes the effect of phosphatidylinositol 3′-kinase, can be mutated or lost, whereas the PIK3CA gene is mutated. These have been proposed as alternative mechanisms, and their cli...

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Veröffentlicht in:	Clinical cancer research 2007-06, Vol.13 (12), p.3577-3584
Hauptverfasser:	Perez-Tenorio, Gizeh, Alkhori, Liza, Olsson, Birgit, Waltersson, Marie Ahnstroem, Nordenskjoeld, Bo, Rutqvist, Lars Erik, Skoog, Lambert, Staal, Olle
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Base Sequence Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Class I Phosphatidylinositol 3-Kinases Female Gene Expression Humans Immunohistochemistry Kirurgi MEDICIN MEDICINE Molecular Sequence Data Mutation Oncology Onkologi Phosphatidylinositol 3-Kinases - genetics PIK3CA Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Prognosis PTEN PTEN Phosphohydrolase - metabolism Surgery tamoxifen
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