Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography
To the Editor: Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated to be less than 30% of that in a healthy person. 1 In fact, most patients resume insulin treatment wit...
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| Veröffentlicht in: | The New England journal of medicine 2007-06, Vol.356 (26), p.2754-2755 |
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| container_issue | 26 |
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| container_title | The New England journal of medicine |
| container_volume | 356 |
| creator | Eich, Torsten Lundgren, Torbjörn Eriksson, Olof |
| description | To the Editor:
Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated to be less than 30% of that in a healthy person.
1
In fact, most patients resume insulin treatment within 2 years after transplantation.
2
Islet-cell transplantation is accomplished by embolizing the islets by means of the portal vein into the liver.
3
Because available tools to study transplanted islets have been limited, the liver has been considered a “black box” in clinical islet transplantation. Here we demonstrate the use of scanning with positron-emission tomography . . . |
| doi_str_mv | 10.1056/NEJMc070201 |
| format | Article |
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Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated to be less than 30% of that in a healthy person.
1
In fact, most patients resume insulin treatment within 2 years after transplantation.
2
Islet-cell transplantation is accomplished by embolizing the islets by means of the portal vein into the liver.
3
Because available tools to study transplanted islets have been limited, the liver has been considered a “black box” in clinical islet transplantation. Here we demonstrate the use of scanning with positron-emission tomography . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>ISSN: 1533-4406</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMc070201</identifier><identifier>PMID: 17596618</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Autoradiography ; C-Peptide - blood ; Diabetes Mellitus, Type 1 - surgery ; Fluorodeoxyglucose F18 - pharmacokinetics ; Graft Survival ; Humans ; Islets of Langerhans Transplantation ; Liver - cytology ; Liver - diagnostic imaging ; Liver - metabolism ; Male ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Positron-Emission Tomography ; Tomography, X-Ray Computed</subject><ispartof>The New England journal of medicine, 2007-06, Vol.356 (26), p.2754-2755</ispartof><rights>Copyright © 2007 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c651t-c03124bc3ade98b35da981b7bea38dead5ec3b04b901fd10139e7e0e60e05c293</citedby><cites>FETCH-LOGICAL-c651t-c03124bc3ade98b35da981b7bea38dead5ec3b04b901fd10139e7e0e60e05c293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMc070201$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223918329?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,781,785,886,2760,2761,26108,27929,27930,52387,54069,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17596618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103621$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:115473863$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Eich, Torsten</creatorcontrib><creatorcontrib>Lundgren, Torbjörn</creatorcontrib><creatorcontrib>Eriksson, Olof</creatorcontrib><creatorcontrib>Nordic Network for Clinical Islet Transplantation</creatorcontrib><title>Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated to be less than 30% of that in a healthy person.
1
In fact, most patients resume insulin treatment within 2 years after transplantation.
2
Islet-cell transplantation is accomplished by embolizing the islets by means of the portal vein into the liver.
3
Because available tools to study transplanted islets have been limited, the liver has been considered a “black box” in clinical islet transplantation. Here we demonstrate the use of scanning with positron-emission tomography . . .</description><subject>Autoradiography</subject><subject>C-Peptide - blood</subject><subject>Diabetes Mellitus, Type 1 - surgery</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Islets of Langerhans Transplantation</subject><subject>Liver - cytology</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography</subject><subject>Tomography, X-Ray Computed</subject><issn>0028-4793</issn><issn>1533-4406</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ks1v1DAQxS0EokvhxB1FIHGBwEycOPGxWgIUlY_D0qvlJLPFS2IHOxFa_nq8ZKEIUV9sjX7vjfz0GHuI8AKhEC8_1O_et1BCBniLrbDgPM1zELfZCiCr0ryU_ITdC2EH8WAu77ITLAspBFYr1l2aMOve_NCTcTZx26TWvt8ntb3yejsNZKfE2GTdG2ta3Sfnoacp2Xhtw9hrOy2yZp98csFM3tm0HkwIh-HGDS6ajF_299mdre4DPTjep-zz63qzfptefHxzvj67SFtR4JS2wDHLm5brjmTV8KLTssKmbEjzqiPdFdTyBvJGAm47BOSSSgISQFC0meSnLF18w3ca50aN3gza75XTRh1HX-OLVCFkXmLk5Y386F13LfotRCzykleCR-3zG7WvzOWZcv5KzbNC4CI7rHq64NH320xhUjGmlvqYIbk5qBKEqCCHCD7-B9y52dsYm8oyLrHivz76bIFa70LwtP2zHkEdSqH-KkWkHx0t52ag7po9tiACTxZgGIKytBv-a_MTL9u_LQ</recordid><startdate>20070628</startdate><enddate>20070628</enddate><creator>Eich, Torsten</creator><creator>Lundgren, Torbjörn</creator><creator>Eriksson, Olof</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>BTSUP</scope><scope>DF2</scope></search><sort><creationdate>20070628</creationdate><title>Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography</title><author>Eich, Torsten ; Lundgren, Torbjörn ; Eriksson, Olof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c651t-c03124bc3ade98b35da981b7bea38dead5ec3b04b901fd10139e7e0e60e05c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Autoradiography</topic><topic>C-Peptide - blood</topic><topic>Diabetes Mellitus, Type 1 - surgery</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Islets of Langerhans Transplantation</topic><topic>Liver - cytology</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>MEDICIN</topic><topic>Medicin och hälsovetenskap</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eich, Torsten</creatorcontrib><creatorcontrib>Lundgren, Torbjörn</creatorcontrib><creatorcontrib>Eriksson, Olof</creatorcontrib><creatorcontrib>Nordic Network for Clinical Islet Transplantation</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SwePub Editorial</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eich, Torsten</au><au>Lundgren, Torbjörn</au><au>Eriksson, Olof</au><aucorp>Nordic Network for Clinical Islet Transplantation</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2007-06-28</date><risdate>2007</risdate><volume>356</volume><issue>26</issue><spage>2754</spage><epage>2755</epage><pages>2754-2755</pages><issn>0028-4793</issn><issn>1533-4406</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>To the Editor:
Although islet transplantation is an option for patients with type 1 diabetes, even those who become insulin-independent after engraftment have islet-graft function that is estimated to be less than 30% of that in a healthy person.
1
In fact, most patients resume insulin treatment within 2 years after transplantation.
2
Islet-cell transplantation is accomplished by embolizing the islets by means of the portal vein into the liver.
3
Because available tools to study transplanted islets have been limited, the liver has been considered a “black box” in clinical islet transplantation. Here we demonstrate the use of scanning with positron-emission tomography . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>17596618</pmid><doi>10.1056/NEJMc070201</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2007-06, Vol.356 (26), p.2754-2755 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Autoradiography C-Peptide - blood Diabetes Mellitus, Type 1 - surgery Fluorodeoxyglucose F18 - pharmacokinetics Graft Survival Humans Islets of Langerhans Transplantation Liver - cytology Liver - diagnostic imaging Liver - metabolism Male MEDICIN Medicin och hälsovetenskap MEDICINE Middle Aged Positron-Emission Tomography Tomography, X-Ray Computed |
| title | Visualization of Early Engraftment in Clinical Islet Transplantation by Positron-Emission Tomography |
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