DNA–VLP prime–boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity

Abstract The immune response to HIV-1 virus-like particles (VLPs), presenting a clade A Ugandan gp120, has been evaluated in a mouse model by intra-nasal (i.n.) administration by a VLP + VLP homologous or a DNA + VLP heterologous prime–boost immunization protocol, including a HIV-1 DNA gp160/rev pla...

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Veröffentlicht in:	Vaccine 2007-08, Vol.25 (32), p.5968-5977
Hauptverfasser:	Buonaguro, L, Devito, C, Tornesello, M.L, Schröder, U, Wahren, B, Hinkula, J, Buonaguro, F.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Administration, Intranasal AIDS AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Allergy and Immunology Animals Antigens Applied microbiology Biological and medical sciences Deoxyribonucleic acid DNA Epitope Mapping Epitopes, B-Lymphocyte - immunology Female Fundamental and applied biological sciences. Psychology HIV Antibodies - blood HIV Antibodies - immunology HIV Envelope Protein gp160 - immunology HIV-1 HIV-1 - classification HIV-1 - immunology Human immunodeficiency virus 1 Humoral immunity Immune response Immune system Immunity, Cellular - immunology Immunity, Mucosal - immunology Immunization Immunization, Secondary Immunogenicity Immunoglobulin G - blood Infections Laboratories Lymph Nodes - cytology Lymph Nodes - immunology MEDICIN MEDICINE Mice Microbiology Miscellaneous Mucosal adjuvants Mucosal response Prime–boost approach Proteins Spleen - cytology Spleen - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Viral infections Virology Virus-like particles (VLP)
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