MTERF3 is a negative regulator of mammalian mtDNA transcription

Regulation of mammalian mtDNA gene expression is critical for altering oxidative phosphorylation capacity in response to physiological demands and disease processes. The basal machinery for initiation of mtDNA transcription has been molecularly defined, but the mechanisms regulating its activity are...

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Veröffentlicht in:	Cell 2007-07, Vol.130 (2), p.273-285
Hauptverfasser:	Park, Chan Bae, Asin-Cayuela, Jorge, Cámara, Yolanda, Shi, Yonghong, Pellegrini, Mina, Gaspari, Martina, Wibom, Rolf, Hultenby, Kjell, Erdjument-Bromage, Hediye, Tempst, Paul, Falkenberg, Maria, Gustafsson, Claes M, Larsson, Nils-Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA, Mitochondrial - genetics Down-Regulation - genetics Electron Transport Embryo, Mammalian - metabolism Embryonic Development Gene Targeting Genes, Essential HeLa Cells Humans Medicin och hälsovetenskap Mice Mice, Knockout Mitochondria - pathology Mitochondrial Proteins - metabolism Myocardium - pathology Myocardium - ultrastructure Organ Specificity Phenotype Promoter Regions, Genetic - genetics Protein Binding RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - metabolism Transcription, Genetic
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