Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice

The inferior performance of DBA/2 mice when compared to C57BL/6 mice in hippocampus‐dependent behavioral tasks including contextual fear conditioning has been attributed to impaired hippocampal function. However, DBA/2J mice have been reported to perform similarly or even better than C57BL/6J mice i...

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Veröffentlicht in:Hippocampus 2008-01, Vol.18 (1), p.11-19
Hauptverfasser: Baarendse, Petra J.J., van Grootheest, Gerard, Jansen, René F., Pieneman, Anton W., Ögren, Sven Ove, Verhage, Matthijs, Stiedl, Oliver
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container_issue 1
container_start_page 11
container_title Hippocampus
container_volume 18
creator Baarendse, Petra J.J.
van Grootheest, Gerard
Jansen, René F.
Pieneman, Anton W.
Ögren, Sven Ove
Verhage, Matthijs
Stiedl, Oliver
description The inferior performance of DBA/2 mice when compared to C57BL/6 mice in hippocampus‐dependent behavioral tasks including contextual fear conditioning has been attributed to impaired hippocampal function. However, DBA/2J mice have been reported to perform similarly or even better than C57BL/6J mice in the passive avoidance (PA) task that most likely also depends on hippocampal function. The apparent discrepancy in PA versus fear conditioning performance in these two strains of mice was investigated using an automated PA system. The aim was to determine whether these two mouse strains utilize different strategies involving a different contribution of hippocampal mechanisms to encode PA. C57BL/6J mice exhibited significantly longer retention latencies than DBA/2J mice when tested 24 h after training irrespective of the circadian cycle. Dorsohippocampal NMDA receptor inhibition by local injection of the selective antagonist DL‐2‐amino‐5‐phosphonovaleric acid (AP5, 3.2 μg/mouse) before training resulted in impaired PA retention in C57BL/6J but not in DBA/2J mice. Furthermore, nonreinforced pre‐exposure to the PA system before training caused a latent inhibition‐like reduction of retention latencies in C57BL/6J, whereas it improved PA retention in DBA/2J mice. These pre‐exposure experiments facilitated the discrimination of hippocampal involvement without local pharmacological intervention. The results indicate differences in PA learning between these two strains based on a different NMDA receptor involvement in the dorsal hippocampus in this emotional learning task. We hypothesize that mouse strains can differ in their PA learning performance based on their relative ability to form associations on the basis of unisensory versus multisensory contextual/spatial cues that involve hippocampal processing. © 2007 Wiley‐Liss, Inc.
doi_str_mv 10.1002/hipo.20356
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However, DBA/2J mice have been reported to perform similarly or even better than C57BL/6J mice in the passive avoidance (PA) task that most likely also depends on hippocampal function. The apparent discrepancy in PA versus fear conditioning performance in these two strains of mice was investigated using an automated PA system. The aim was to determine whether these two mouse strains utilize different strategies involving a different contribution of hippocampal mechanisms to encode PA. C57BL/6J mice exhibited significantly longer retention latencies than DBA/2J mice when tested 24 h after training irrespective of the circadian cycle. Dorsohippocampal NMDA receptor inhibition by local injection of the selective antagonist DL‐2‐amino‐5‐phosphonovaleric acid (AP5, 3.2 μg/mouse) before training resulted in impaired PA retention in C57BL/6J but not in DBA/2J mice. 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subjects 2-Amino-5-phosphonovalerate - pharmacology
Analysis of Variance
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Behavior, Animal - drug effects
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
Excitatory Amino Acid Antagonists - pharmacology
fear conditioning
Hippocampus - drug effects
Hippocampus - physiology
Inhibition (Psychology)
latent inhibition
learning and memory
Male
Medicin och hälsovetenskap
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
multisensory associations
Reaction Time - drug effects
Reaction Time - physiology
Species Specificity
strain comparison
title Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice
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