Large-Scale Zygosity Testing Using Single Nucleotide Polymorphisms

A requirement for performing robust genetic and statistical analyses on twins is correctly assigned zygosities. In order to increase the power to detect small risk factors of disease, zygosity testing should also be amenable for high throughput screening. In this study we validate and implement the...

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Veröffentlicht in:	Twin research and human genetics 2007-08, Vol.10 (4), p.604-625
Hauptverfasser:	Hannelius, Ulf, Gherman, Loreana, Mäkelä, Ville-Veikko, Lindstedt, Astrid, Zucchelli, Marco, Lagerberg, Camilla, Tybring, Gunnel, Kere, Juha, Lindgren, Cecilia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Deoxyribonucleic acid Diagnosis DNA Female Filter paper Gene frequency Genetic analysis Genetic disorders Genome, Human Genotype Genotyping High-throughput screening Human genetics Humans Male Medicin och hälsovetenskap Microsatellite Repeats Nucleic Acid Amplification Techniques Polymorphism, Single Nucleotide Reproducibility of Results Risk factors Saliva Sensitivity analysis Sensitivity and Specificity Short tandem repeats Short tandem repeats (STRs) Single nucleotide polymorphism (SNP) Single-nucleotide polymorphism Statistical analysis Twins, Dizygotic - genetics Twins, Monozygotic - genetics Zygosity Zygotes
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