TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

A genomewide association study of North American and Swedish patients with rheumatoid arthritis who were seropositive for autoantibodies against cyclic citrullinated peptide yielded susceptibility variants in the usual suspects: HLA-DRB1 and PTPN22 . A new locus was also implicated: a SNP that lies...

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Veröffentlicht in:	The New England journal of medicine 2007-09, Vol.357 (12), p.1199-1209
Hauptverfasser:	Plenge, Robert M, Seielstad, Mark, Padyukov, Leonid, Lee, Annette T, Remmers, Elaine F, Ding, Bo, Liew, Anthony, Khalili, Houman, Chandrasekaran, Alamelu, Davies, Leela R.L, Li, Wentian, Tan, Adrian K.S, Bonnard, Carine, Ong, Rick T.H, Thalamuthu, Anbupalam, Pettersson, Sven, Liu, Chunyu, Tian, Chao, Chen, Wei V, Carulli, John P, Beckman, Evan M, Altshuler, David, Alfredsson, Lars, Criswell, Lindsey A, Amos, Christopher I, Seldin, Michael F, Kastner, Daniel L, Klareskog, Lars, Gregersen, Peter K
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - blood Biological and medical sciences Case-Control Studies Chromosome Mapping Chromosomes, Human, Pair 9 - genetics Complement C5 - genetics Disease Epidemiology Genealogy General aspects Genetic Predisposition to Disease Genetics Genomes Genotype HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Linkage Disequilibrium Logistic Models Medical sciences Peptides, Cyclic - immunology Polymorphism, Single Nucleotide Protein Tyrosine Phosphatase, Non-Receptor Type 22 Protein Tyrosine Phosphatases - genetics Public health. Hygiene Public health. Hygiene-occupational medicine Rheumatic diseases Rheumatoid arthritis Rheumatology Risk Factors Sequence Analysis, DNA TNF Receptor-Associated Factor 1 - genetics
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