Early life events and conditions and breast cancer risk: From epidemiology to etiology
Risk factors for breast cancer—documented by intensive epidemiological investigations and viewed in the context of general principles of carcinogenesis—can be integrated to an etiologic model comprising 3 principal components: the likelihood of breast cancer occurrence depends on the number of mamma...
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| Veröffentlicht in: | International journal of cancer 2008-02, Vol.122 (3), p.481-485 |
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| container_title | International journal of cancer |
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| creator | Trichopoulos, Dimitrios Adami, Hans‐Olov Ekbom, Anders Hsieh, Chung‐Cheng Lagiou, Pagona |
| description | Risk factors for breast cancer—documented by intensive epidemiological investigations and viewed in the context of general principles of carcinogenesis—can be integrated to an etiologic model comprising 3 principal components: the likelihood of breast cancer occurrence depends on the number of mammary tissue‐specific stem cells, which is determined in early life; all growth‐enhancing mammotropic hormones affect the rate of expansion of initiated clones; and while a pregnancy stimulates the replication of already initiated cells, it conveys long‐term protection through differentiation of mammary tissue‐specific stem cells. This perspective accommodates much of what is known about the epidemiology and natural history of breast cancer and highlights the role of early life in the origin of this cancer. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.23303 |
| format | Article |
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This perspective accommodates much of what is known about the epidemiology and natural history of breast cancer and highlights the role of early life in the origin of this cancer. © 2007 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>birth weight</subject><subject>breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hormones</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>perinatal</subject><subject>pregnancy</subject><subject>Risk Factors</subject><subject>stem cells</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFvFSEUhYnR2Gd14R8wbDRxMe1lGBhw17y0WtPEjbolDNwxtDPDE-bZvH8v7Yy-VVdc4DvnBA4hbxmcMYD6PNy6s5pz4M_IhoFuK6iZeE425Q6qlnF5Ql7lfAvAmIDmJTlhCupa6XZDfl7aNBzoEHqk-AenOVM7eeri5MMc4rRsu4Q2z9TZyWGiKeS7T_QqxZHiLngcQxzirwOdI8V5mV-TF70dMr5Z11Py4-ry-_ZLdfPt8_X24qZyAlpetb2zSnTQNdC0vte-RQaIsnNSowXJuk5rpbzqG8UFB4deoJPKeV9eIpCfkmrxzfe423dml8Jo08FEG8x6dFcmNEK25U8Kr5_kdyn6o-ifkDHJG8GFLNoPi7aAv_eYZzOG7HAY7IRxn00Nsq6lfgA_LqBLMeeE_f8YBuahMFMKM4-FFfbdarrvRvRHcm2oAO9XwGZnhz6VDkI-clqDgkej84W7DwMenk4011-3S_RfwDGuJw</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Trichopoulos, Dimitrios</creator><creator>Adami, Hans‐Olov</creator><creator>Ekbom, Anders</creator><creator>Hsieh, Chung‐Cheng</creator><creator>Lagiou, Pagona</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20080201</creationdate><title>Early life events and conditions and breast cancer risk: From epidemiology to etiology</title><author>Trichopoulos, Dimitrios ; Adami, Hans‐Olov ; Ekbom, Anders ; Hsieh, Chung‐Cheng ; Lagiou, Pagona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5073-7fca85b0b4047df9d7e10ee6bc69ea061bb9988d8f483530ced5ec68cdd1505e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>birth weight</topic><topic>breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Gynecology. 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Obstetrics</topic><topic>hormones</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>perinatal</topic><topic>pregnancy</topic><topic>Risk Factors</topic><topic>stem cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trichopoulos, Dimitrios</creatorcontrib><creatorcontrib>Adami, Hans‐Olov</creatorcontrib><creatorcontrib>Ekbom, Anders</creatorcontrib><creatorcontrib>Hsieh, Chung‐Cheng</creatorcontrib><creatorcontrib>Lagiou, Pagona</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trichopoulos, Dimitrios</au><au>Adami, Hans‐Olov</au><au>Ekbom, Anders</au><au>Hsieh, Chung‐Cheng</au><au>Lagiou, Pagona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early life events and conditions and breast cancer risk: From epidemiology to etiology</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>122</volume><issue>3</issue><spage>481</spage><epage>485</epage><pages>481-485</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>Risk factors for breast cancer—documented by intensive epidemiological investigations and viewed in the context of general principles of carcinogenesis—can be integrated to an etiologic model comprising 3 principal components: the likelihood of breast cancer occurrence depends on the number of mammary tissue‐specific stem cells, which is determined in early life; all growth‐enhancing mammotropic hormones affect the rate of expansion of initiated clones; and while a pregnancy stimulates the replication of already initiated cells, it conveys long‐term protection through differentiation of mammary tissue‐specific stem cells. 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| ispartof | International journal of cancer, 2008-02, Vol.122 (3), p.481-485 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences birth weight breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - etiology Breast Neoplasms - pathology Gynecology. Andrology. Obstetrics hormones Humans Mammary gland diseases Medical sciences Medicin och hälsovetenskap perinatal pregnancy Risk Factors stem cells Tumors |
| title | Early life events and conditions and breast cancer risk: From epidemiology to etiology |
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