Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls. We found 16 SNPs and two...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2008-03, Vol.17 (6), p.872-881
Hauptverfasser:	Sigurdsson, Snaevar, Göring, Harald H.H., Kristjansdottir, Gudlaug, Milani, Lili, Nordmark, Gunnel, Sandling, Johanna K., Eloranta, Maija-Leena, Feng, Di, Sangster-Guity, Niquiche, Gunnarsson, Iva, Svenungsson, Elisabet, Sturfelt, Gunnar, Jönsen, Andreas, Truedsson, Lennart, Barnes, Betsy J., Alm, Gunnar, Rönnblom, Lars, Syvänen, Ann-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Basic Medicine Biological and medical sciences Blotting, Western Case-Control Studies Electrophoretic Mobility Shift Assay Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotype Humans Interferon Regulatory Factors - genetics Lupus Erythematosus, Systemic - genetics Medical and Health Sciences Medical Genetics Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Molecular and cellular biology Polymorphism, Single Nucleotide Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!