Developmental switch of intestinal antimicrobial peptide expression

Paneth cell-derived enteric antimicrobial peptides provide protection from intestinal infection and maintenance of enteric homeostasis. Paneth cells, however, evolve only after the neonatal period, and the antimicrobial mechanisms that protect the newborn intestine are ill defined. Using quantitativ...

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Veröffentlicht in:	The Journal of experimental medicine 2008-01, Vol.205 (1), p.183-193
Hauptverfasser:	Ménard, Sandrine, Förster, Valentina, Lotz, Michael, Gütle, Dominique, Duerr, Claudia U, Gallo, Richard L, Henriques-Normark, Birgitta, Pütsep, Katrin, Andersson, Mats, Glocker, Erik O, Hornef, Mathias W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - physiology Cathelicidins Cell Movement Cell Proliferation Chromatography, High Pressure Liquid Epithelial Cells - cytology Epithelial Cells - metabolism Gene Expression Regulation, Developmental Intestinal Mucosa - metabolism Listeria monocytogenes Mass Spectrometry - methods Mice Mice, Inbred C57BL Reverse Transcriptase Polymerase Chain Reaction Time Factors
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