Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens

Long-term changes in the efficacy of glutamatergic synaptic transmission in the striatal complex are proposed to underlie motor learning and neuroadaptations leading to addiction. Dopamine and glutamate play key roles in the induction of long-term potentiation (LTP) and long-term depression (LTD) in...

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Veröffentlicht in:	Neuropharmacology 2008-04, Vol.54 (5), p.837-844
Hauptverfasser:	Schotanus, Sietske M., Chergui, Karima
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - pharmacology Benzazepines - pharmacology Benzoates - pharmacology Bicuculline - pharmacology Dopamine Antagonists - pharmacology Dopamine receptors Dose-Response Relationship, Radiation Electric Stimulation - methods Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects Field excitatory postsynaptic potential GABA Antagonists - pharmacology Glycine - analogs & derivatives Glycine - pharmacology In Vitro Techniques Long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Long-Term Potentiation - radiation effects Male Medicin och hälsovetenskap Metabotropic glutamate receptors Mice Mice, Inbred C57BL Mouse Nucleus accumbens Nucleus Accumbens - physiology Phosphinic Acids - pharmacology Propanolamines - pharmacology Pyridines - pharmacology Receptors, Dopamine D1 - physiology Receptors, Metabotropic Glutamate - physiology Sulpiride - pharmacology
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