C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice

Objectives:To assess the human complement inhibitor C4b-binding protein (C4BP) for treatment of arthritis.Methods:We have used two mouse models of rheumatoid arthritis (RA) to assess the therapeutic effect of C4BP on different phases of arthritis, the collagen antibody-induced arthritis (CAIA), an a...

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Veröffentlicht in:	Annals of the rheumatic diseases 2009-01, Vol.68 (1), p.136-142
Hauptverfasser:	Blom, A M, Nandakumar, K S, Holmdahl, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Experimental - prevention & control Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - prevention & control Clinical Medicine Collagen Collagen - immunology Complement C4b - immunology Complement C4b-Binding Protein - therapeutic use Complement Pathway, Alternative - drug effects Complement Pathway, Classical - drug effects Disease Experiments Government agencies Humans Immunoglobulins Inflammatory diseases Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Mice Mice, Mutant Strains Neutrophils Pathogenesis Plasma Proteins Reumatologi och inflammation Rheumatology and Autoimmunity Rodents
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