Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling

The Notch receptor is essential for neural stem cell (NSC) characteristics. Relatively high concentrations (micromolar) of methylmercury (MeHg) activate Notch signalling in Drosophila cell lines; however, exposure of MeHg at such concentrations is rare, and the implications for mammalian cells are u...

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Veröffentlicht in:	Neuroreport 2008-02, Vol.19 (3), p.339-343
Hauptverfasser:	Tamm, Christoffer, Duckworth, Joshua K, Hermanson, Ola, Ceccatelli, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cell Differentiation - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Dipeptides - pharmacology Drosophila Female Manganese - pharmacology Matrix Metalloproteinase Inhibitors Medical sciences Metals and various inorganic compounds Methylmercury Compounds - toxicity Neurons - drug effects Pregnancy Protease Inhibitors - pharmacology Rats Rats, Sprague-Dawley Receptors, Notch - drug effects Receptors, Notch - genetics Receptors, Notch - physiology Signal Transduction - drug effects Stem Cells - drug effects Telencephalon - cytology Toxicology Transfection
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