Diabetic osteopathy and the IGF system in the Goto–Kakizaki rat
Abstract Objective Diabetes mellitus is associated with an increased risk of osteopenia, fracture and Charcot arthropathy. Abnormalities of the IGF system commonly observed in diabetes may underlie this “diabetic osteopathy” as IGF-I and its binding proteins (IGFBPs) have been shown to affect osteob...
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| Veröffentlicht in: | Growth hormone & IGF research 2008-10, Vol.18 (5), p.404-411 |
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| creator | Ahmad, Tashfeen Ugarph-Morawski, Anna Lewitt, Moira S Li, Jian Sääf, Maria Brismar, Kerstin |
| description | Abstract Objective Diabetes mellitus is associated with an increased risk of osteopenia, fracture and Charcot arthropathy. Abnormalities of the IGF system commonly observed in diabetes may underlie this “diabetic osteopathy” as IGF-I and its binding proteins (IGFBPs) have been shown to affect osteoblast and osteoclast activity. Design In type-2 diabetic and control rats we analyzed IGF-I and IGFBP-1 and -4 levels in serum, and notably, also the IGF-I levels in cortical bone, ankles and vertebrae by immunoassays. Osteopathy was assessed by radiography and dual energy X-ray absorptiometry. Results In the diabetic rats IGF-I was significantly reduced in serum and diaphyseal bone while IGFBP-1 and IGFBP-4 were increased in serum. The periosteal and endosteal diameters were increased in the diaphysis of humerus and tibia (changes similar to those in elderly humans) while bone mineral density was reduced in long bone metaphyses and vertebrae. Conclusions Our study demonstrates both systemic and local disturbances of the IGF-system in rats with type-2 diabetes, consistent with the observed enhanced endosteal erosion in long bone diaphyses, and osteopenia in metaphyses and vertebrae. Whether similar IGF-system changes contribute to osteopathy in patients with diabetes and if treatment of diabetes can reverse the osteopathy has yet to be explored. |
| doi_str_mv | 10.1016/j.ghir.2008.02.003 |
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| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_565087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1096637408000397</els_id><sourcerecordid>69316577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-faf6293ea9c700ea7342f85a29eff7c51cb48ee3d82c4384637c461e5baf780a3</originalsourceid><addsrcrecordid>eNp9kc2KFDEUhYMozjj6Ai6kVu6qvEnqJwUiDKPTDg64UNeXVOqWne7qSpukRtqV7-Ab-iSm7EbBhYuQy-E7h8u5jD3lUHDg9YtN8XltfSEAVAGiAJD32DmvpMiFkOp-mqGt81o25Rl7FMIGAFqpyofsjCupuCirc3b52uqOojWZC5HcXsf1IdNTn8U1ZTer6ywckr7L7PRbWbnofn7_8U5v7bf0Mq_jY_Zg0GOgJ6f_gn26fvPx6m1--351c3V5m5uKy5gPeqhFK0m3pgEg3chSDKrSoqVhaBJjulIRyV4JU6Yt09qmrDlVnR4aBVpesPyYG77Sfu5w7-1O-wM6bfEkbdNEWNUVqCbxz4_83rsvM4WIOxsMjaOeyM0B61byumoWUBxB410InoY_0RxwKRo3uBSNS9EIAlPRyfTslD53O-r_Wk7NJuDlEaDUyZ0lj8FYmgz11pOJ2Dv7__xX_9jNaCdr9LilA4WNm_2U2kaOIRnww3Lq5dKg0pVl28hfB0mkdQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69316577</pqid></control><display><type>article</type><title>Diabetic osteopathy and the IGF system in the Goto–Kakizaki rat</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Ahmad, Tashfeen ; Ugarph-Morawski, Anna ; Lewitt, Moira S ; Li, Jian ; Sääf, Maria ; Brismar, Kerstin</creator><creatorcontrib>Ahmad, Tashfeen ; Ugarph-Morawski, Anna ; Lewitt, Moira S ; Li, Jian ; Sääf, Maria ; Brismar, Kerstin</creatorcontrib><description>Abstract Objective Diabetes mellitus is associated with an increased risk of osteopenia, fracture and Charcot arthropathy. Abnormalities of the IGF system commonly observed in diabetes may underlie this “diabetic osteopathy” as IGF-I and its binding proteins (IGFBPs) have been shown to affect osteoblast and osteoclast activity. Design In type-2 diabetic and control rats we analyzed IGF-I and IGFBP-1 and -4 levels in serum, and notably, also the IGF-I levels in cortical bone, ankles and vertebrae by immunoassays. Osteopathy was assessed by radiography and dual energy X-ray absorptiometry. Results In the diabetic rats IGF-I was significantly reduced in serum and diaphyseal bone while IGFBP-1 and IGFBP-4 were increased in serum. The periosteal and endosteal diameters were increased in the diaphysis of humerus and tibia (changes similar to those in elderly humans) while bone mineral density was reduced in long bone metaphyses and vertebrae. Conclusions Our study demonstrates both systemic and local disturbances of the IGF-system in rats with type-2 diabetes, consistent with the observed enhanced endosteal erosion in long bone diaphyses, and osteopenia in metaphyses and vertebrae. Whether similar IGF-system changes contribute to osteopathy in patients with diabetes and if treatment of diabetes can reverse the osteopathy has yet to be explored.</description><identifier>ISSN: 1096-6374</identifier><identifier>EISSN: 1532-2238</identifier><identifier>DOI: 10.1016/j.ghir.2008.02.003</identifier><identifier>PMID: 18381245</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Animals ; Bone and Bones - diagnostic imaging ; Bone and Bones - metabolism ; Bone Diseases, Metabolic - complications ; Bone Diseases, Metabolic - diagnostic imaging ; Bone Diseases, Metabolic - metabolism ; Bone mineral density ; Diabetes Complications - blood ; Diabetes Complications - diagnostic imaging ; Diabetes Complications - metabolism ; Diabetes mellitus type-2 ; Diabetes Mellitus, Type 2 - complications ; Diaphyses - diagnostic imaging ; Endocrinology & Metabolism ; Female ; Fractures, Bone - complications ; Goto–Kakizaki rat ; Insulin-like growth factor 1 ; Insulin-like growth factor binding protein 1 ; Insulin-Like Growth Factor Binding Protein 1 - blood ; Insulin-like growth factor binding protein 4 ; Insulin-Like Growth Factor Binding Protein 4 - blood ; Insulin-Like Growth Factor I - metabolism ; Radiography ; Rats ; Rats, Wistar</subject><ispartof>Growth hormone & IGF research, 2008-10, Vol.18 (5), p.404-411</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-faf6293ea9c700ea7342f85a29eff7c51cb48ee3d82c4384637c461e5baf780a3</citedby><cites>FETCH-LOGICAL-c513t-faf6293ea9c700ea7342f85a29eff7c51cb48ee3d82c4384637c461e5baf780a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ghir.2008.02.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18381245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:117487926$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmad, Tashfeen</creatorcontrib><creatorcontrib>Ugarph-Morawski, Anna</creatorcontrib><creatorcontrib>Lewitt, Moira S</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Sääf, Maria</creatorcontrib><creatorcontrib>Brismar, Kerstin</creatorcontrib><title>Diabetic osteopathy and the IGF system in the Goto–Kakizaki rat</title><title>Growth hormone & IGF research</title><addtitle>Growth Horm IGF Res</addtitle><description>Abstract Objective Diabetes mellitus is associated with an increased risk of osteopenia, fracture and Charcot arthropathy. Abnormalities of the IGF system commonly observed in diabetes may underlie this “diabetic osteopathy” as IGF-I and its binding proteins (IGFBPs) have been shown to affect osteoblast and osteoclast activity. Design In type-2 diabetic and control rats we analyzed IGF-I and IGFBP-1 and -4 levels in serum, and notably, also the IGF-I levels in cortical bone, ankles and vertebrae by immunoassays. Osteopathy was assessed by radiography and dual energy X-ray absorptiometry. Results In the diabetic rats IGF-I was significantly reduced in serum and diaphyseal bone while IGFBP-1 and IGFBP-4 were increased in serum. The periosteal and endosteal diameters were increased in the diaphysis of humerus and tibia (changes similar to those in elderly humans) while bone mineral density was reduced in long bone metaphyses and vertebrae. Conclusions Our study demonstrates both systemic and local disturbances of the IGF-system in rats with type-2 diabetes, consistent with the observed enhanced endosteal erosion in long bone diaphyses, and osteopenia in metaphyses and vertebrae. Whether similar IGF-system changes contribute to osteopathy in patients with diabetes and if treatment of diabetes can reverse the osteopathy has yet to be explored.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Diseases, Metabolic - complications</subject><subject>Bone Diseases, Metabolic - diagnostic imaging</subject><subject>Bone Diseases, Metabolic - metabolism</subject><subject>Bone mineral density</subject><subject>Diabetes Complications - blood</subject><subject>Diabetes Complications - diagnostic imaging</subject><subject>Diabetes Complications - metabolism</subject><subject>Diabetes mellitus type-2</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diaphyses - diagnostic imaging</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Fractures, Bone - complications</subject><subject>Goto–Kakizaki rat</subject><subject>Insulin-like growth factor 1</subject><subject>Insulin-like growth factor binding protein 1</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - blood</subject><subject>Insulin-like growth factor binding protein 4</subject><subject>Insulin-Like Growth Factor Binding Protein 4 - blood</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1096-6374</issn><issn>1532-2238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMozjj6Ai6kVu6qvEnqJwUiDKPTDg64UNeXVOqWne7qSpukRtqV7-Ab-iSm7EbBhYuQy-E7h8u5jD3lUHDg9YtN8XltfSEAVAGiAJD32DmvpMiFkOp-mqGt81o25Rl7FMIGAFqpyofsjCupuCirc3b52uqOojWZC5HcXsf1IdNTn8U1ZTer6ywckr7L7PRbWbnofn7_8U5v7bf0Mq_jY_Zg0GOgJ6f_gn26fvPx6m1--351c3V5m5uKy5gPeqhFK0m3pgEg3chSDKrSoqVhaBJjulIRyV4JU6Yt09qmrDlVnR4aBVpesPyYG77Sfu5w7-1O-wM6bfEkbdNEWNUVqCbxz4_83rsvM4WIOxsMjaOeyM0B61byumoWUBxB410InoY_0RxwKRo3uBSNS9EIAlPRyfTslD53O-r_Wk7NJuDlEaDUyZ0lj8FYmgz11pOJ2Dv7__xX_9jNaCdr9LilA4WNm_2U2kaOIRnww3Lq5dKg0pVl28hfB0mkdQ</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Ahmad, Tashfeen</creator><creator>Ugarph-Morawski, Anna</creator><creator>Lewitt, Moira S</creator><creator>Li, Jian</creator><creator>Sääf, Maria</creator><creator>Brismar, Kerstin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20081001</creationdate><title>Diabetic osteopathy and the IGF system in the Goto–Kakizaki rat</title><author>Ahmad, Tashfeen ; Ugarph-Morawski, Anna ; Lewitt, Moira S ; Li, Jian ; Sääf, Maria ; Brismar, Kerstin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-faf6293ea9c700ea7342f85a29eff7c51cb48ee3d82c4384637c461e5baf780a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Diseases, Metabolic - complications</topic><topic>Bone Diseases, Metabolic - diagnostic imaging</topic><topic>Bone Diseases, Metabolic - metabolism</topic><topic>Bone mineral density</topic><topic>Diabetes Complications - blood</topic><topic>Diabetes Complications - diagnostic imaging</topic><topic>Diabetes Complications - metabolism</topic><topic>Diabetes mellitus type-2</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diaphyses - diagnostic imaging</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Fractures, Bone - complications</topic><topic>Goto–Kakizaki rat</topic><topic>Insulin-like growth factor 1</topic><topic>Insulin-like growth factor binding protein 1</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - blood</topic><topic>Insulin-like growth factor binding protein 4</topic><topic>Insulin-Like Growth Factor Binding Protein 4 - blood</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmad, Tashfeen</creatorcontrib><creatorcontrib>Ugarph-Morawski, Anna</creatorcontrib><creatorcontrib>Lewitt, Moira S</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Sääf, Maria</creatorcontrib><creatorcontrib>Brismar, Kerstin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Growth hormone & IGF research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmad, Tashfeen</au><au>Ugarph-Morawski, Anna</au><au>Lewitt, Moira S</au><au>Li, Jian</au><au>Sääf, Maria</au><au>Brismar, Kerstin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetic osteopathy and the IGF system in the Goto–Kakizaki rat</atitle><jtitle>Growth hormone & IGF research</jtitle><addtitle>Growth Horm IGF Res</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>18</volume><issue>5</issue><spage>404</spage><epage>411</epage><pages>404-411</pages><issn>1096-6374</issn><eissn>1532-2238</eissn><abstract>Abstract Objective Diabetes mellitus is associated with an increased risk of osteopenia, fracture and Charcot arthropathy. Abnormalities of the IGF system commonly observed in diabetes may underlie this “diabetic osteopathy” as IGF-I and its binding proteins (IGFBPs) have been shown to affect osteoblast and osteoclast activity. Design In type-2 diabetic and control rats we analyzed IGF-I and IGFBP-1 and -4 levels in serum, and notably, also the IGF-I levels in cortical bone, ankles and vertebrae by immunoassays. Osteopathy was assessed by radiography and dual energy X-ray absorptiometry. Results In the diabetic rats IGF-I was significantly reduced in serum and diaphyseal bone while IGFBP-1 and IGFBP-4 were increased in serum. The periosteal and endosteal diameters were increased in the diaphysis of humerus and tibia (changes similar to those in elderly humans) while bone mineral density was reduced in long bone metaphyses and vertebrae. Conclusions Our study demonstrates both systemic and local disturbances of the IGF-system in rats with type-2 diabetes, consistent with the observed enhanced endosteal erosion in long bone diaphyses, and osteopenia in metaphyses and vertebrae. Whether similar IGF-system changes contribute to osteopathy in patients with diabetes and if treatment of diabetes can reverse the osteopathy has yet to be explored.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>18381245</pmid><doi>10.1016/j.ghir.2008.02.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Advanced Basic Science Animals Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone Diseases, Metabolic - complications Bone Diseases, Metabolic - diagnostic imaging Bone Diseases, Metabolic - metabolism Bone mineral density Diabetes Complications - blood Diabetes Complications - diagnostic imaging Diabetes Complications - metabolism Diabetes mellitus type-2 Diabetes Mellitus, Type 2 - complications Diaphyses - diagnostic imaging Endocrinology & Metabolism Female Fractures, Bone - complications Goto–Kakizaki rat Insulin-like growth factor 1 Insulin-like growth factor binding protein 1 Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-like growth factor binding protein 4 Insulin-Like Growth Factor Binding Protein 4 - blood Insulin-Like Growth Factor I - metabolism Radiography Rats Rats, Wistar |
| title | Diabetic osteopathy and the IGF system in the Goto–Kakizaki rat |
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