Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure

Aims To determine whether the risk of adverse cardiovascular (CV) outcomes associated with diabetes differs in patients with low and preserved ejection fraction (EF) heart failure (HF). Methods and results We analysed outcomes in the Candesartan in Heart failure—Assessment of Reduction in Mortality...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European heart journal 2008-06, Vol.29 (11), p.1377-1385
Hauptverfasser: MacDonald, Michael R., Petrie, Mark C., Varyani, Fumi, Östergren, Jan, Michelson, Eric L., Young, James B., Solomon, Scott D., Granger, Christopher B., Swedberg, Karl, Yusuf, Salim, Pfeffer, Marc A., McMurray, John J.V.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1385
container_issue 11
container_start_page 1377
container_title European heart journal
container_volume 29
creator MacDonald, Michael R.
Petrie, Mark C.
Varyani, Fumi
Östergren, Jan
Michelson, Eric L.
Young, James B.
Solomon, Scott D.
Granger, Christopher B.
Swedberg, Karl
Yusuf, Salim
Pfeffer, Marc A.
McMurray, John J.V.
description Aims To determine whether the risk of adverse cardiovascular (CV) outcomes associated with diabetes differs in patients with low and preserved ejection fraction (EF) heart failure (HF). Methods and results We analysed outcomes in the Candesartan in Heart failure—Assessment of Reduction in Mortality and morbidity (CHARM) programme which randomized 7599 patients with symptomatic HF and a broad range of EF. The prevalence of diabetes was 28.3% in patients with preserved EF (>40%) and 28.5% in those with low EF (≤40%). Diabetes was associated with a greater relative risk of CV death or HF hospitalization in patients with preserved EF [hazard ratio (HR) 2.0 (1.70–2.36)] than in patients with low EF [HR 1.60 (1.44–1.77); interaction test P = 0.0009]. For all-cause mortality, the risk conferred by diabetes was similar in both low and preserved EF groups. The effect of candesartan in reducing CV morbidity and mortality outcomes was not modified by having diabetes at baseline (P = 0.09 test for interaction). Conclusion Diabetes was an independent predictor of CV morbidity and mortality in patients with HF, regardless of EF. The relative risk of CV death or HF hospitalization conferred by diabetes was significantly greater in patients with preserved when compared with those with low EF HF.
doi_str_mv 10.1093/eurheartj/ehn153
format Article
fullrecord <record><control><sourceid>oup_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_564861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/eurheartj/ehn153</oup_id><sourcerecordid>10.1093/eurheartj/ehn153</sourcerecordid><originalsourceid>FETCH-LOGICAL-i197t-979d0514e6218eb3a332fbbab397601cf96c35fed8259bc5a8b584e85d63f42b3</originalsourceid><addsrcrecordid>eNpFkEtPwzAQhC0EEqVw5-g7CrXj2ImPqDxaWgkOgCoulp2sVfeRRLZD4d8TKCqnHa2-He0MQpeUXFMi2Qg6vwTt42oEy5pydoQGlKdpIkXGj9GAUMkTIYrFKToLYUUIKQQVA6Sn21aXETcWV04biBBwU-Omi2Wz7bWrcaujgzoGvHNxiTfNDuu6wq2HAP4DKgwrKKPrj6zXe_H7CLbabToP5-jE6k2Ai785RK_3dy_jSTJ_epiOb-aJozKPicxlRTjNQKS0AMM0Y6k1Rhsmc0FoaaUoGbdQFSmXpuS6MLzIoOCVYDZLDRuiZO8bdtB2RrXebbX_Uo126m-17hUoLrI-e89f7fmmaw8wJeqnTXVoU-3b_Hd3IcLngdd-rUTOcq4mi3f1zG_FYjZ7VG_sG5XxfYo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>MacDonald, Michael R. ; Petrie, Mark C. ; Varyani, Fumi ; Östergren, Jan ; Michelson, Eric L. ; Young, James B. ; Solomon, Scott D. ; Granger, Christopher B. ; Swedberg, Karl ; Yusuf, Salim ; Pfeffer, Marc A. ; McMurray, John J.V.</creator><creatorcontrib>MacDonald, Michael R. ; Petrie, Mark C. ; Varyani, Fumi ; Östergren, Jan ; Michelson, Eric L. ; Young, James B. ; Solomon, Scott D. ; Granger, Christopher B. ; Swedberg, Karl ; Yusuf, Salim ; Pfeffer, Marc A. ; McMurray, John J.V.</creatorcontrib><description>Aims To determine whether the risk of adverse cardiovascular (CV) outcomes associated with diabetes differs in patients with low and preserved ejection fraction (EF) heart failure (HF). Methods and results We analysed outcomes in the Candesartan in Heart failure—Assessment of Reduction in Mortality and morbidity (CHARM) programme which randomized 7599 patients with symptomatic HF and a broad range of EF. The prevalence of diabetes was 28.3% in patients with preserved EF (&gt;40%) and 28.5% in those with low EF (≤40%). Diabetes was associated with a greater relative risk of CV death or HF hospitalization in patients with preserved EF [hazard ratio (HR) 2.0 (1.70–2.36)] than in patients with low EF [HR 1.60 (1.44–1.77); interaction test P = 0.0009]. For all-cause mortality, the risk conferred by diabetes was similar in both low and preserved EF groups. The effect of candesartan in reducing CV morbidity and mortality outcomes was not modified by having diabetes at baseline (P = 0.09 test for interaction). Conclusion Diabetes was an independent predictor of CV morbidity and mortality in patients with HF, regardless of EF. The relative risk of CV death or HF hospitalization conferred by diabetes was significantly greater in patients with preserved when compared with those with low EF HF.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehn153</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Diabetes ; Heart failure</subject><ispartof>European heart journal, 2008-06, Vol.29 (11), p.1377-1385</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:117143411$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>MacDonald, Michael R.</creatorcontrib><creatorcontrib>Petrie, Mark C.</creatorcontrib><creatorcontrib>Varyani, Fumi</creatorcontrib><creatorcontrib>Östergren, Jan</creatorcontrib><creatorcontrib>Michelson, Eric L.</creatorcontrib><creatorcontrib>Young, James B.</creatorcontrib><creatorcontrib>Solomon, Scott D.</creatorcontrib><creatorcontrib>Granger, Christopher B.</creatorcontrib><creatorcontrib>Swedberg, Karl</creatorcontrib><creatorcontrib>Yusuf, Salim</creatorcontrib><creatorcontrib>Pfeffer, Marc A.</creatorcontrib><creatorcontrib>McMurray, John J.V.</creatorcontrib><title>Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure</title><title>European heart journal</title><description>Aims To determine whether the risk of adverse cardiovascular (CV) outcomes associated with diabetes differs in patients with low and preserved ejection fraction (EF) heart failure (HF). Methods and results We analysed outcomes in the Candesartan in Heart failure—Assessment of Reduction in Mortality and morbidity (CHARM) programme which randomized 7599 patients with symptomatic HF and a broad range of EF. The prevalence of diabetes was 28.3% in patients with preserved EF (&gt;40%) and 28.5% in those with low EF (≤40%). Diabetes was associated with a greater relative risk of CV death or HF hospitalization in patients with preserved EF [hazard ratio (HR) 2.0 (1.70–2.36)] than in patients with low EF [HR 1.60 (1.44–1.77); interaction test P = 0.0009]. For all-cause mortality, the risk conferred by diabetes was similar in both low and preserved EF groups. The effect of candesartan in reducing CV morbidity and mortality outcomes was not modified by having diabetes at baseline (P = 0.09 test for interaction). Conclusion Diabetes was an independent predictor of CV morbidity and mortality in patients with HF, regardless of EF. The relative risk of CV death or HF hospitalization conferred by diabetes was significantly greater in patients with preserved when compared with those with low EF HF.</description><subject>Diabetes</subject><subject>Heart failure</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpFkEtPwzAQhC0EEqVw5-g7CrXj2ImPqDxaWgkOgCoulp2sVfeRRLZD4d8TKCqnHa2-He0MQpeUXFMi2Qg6vwTt42oEy5pydoQGlKdpIkXGj9GAUMkTIYrFKToLYUUIKQQVA6Sn21aXETcWV04biBBwU-Omi2Wz7bWrcaujgzoGvHNxiTfNDuu6wq2HAP4DKgwrKKPrj6zXe_H7CLbabToP5-jE6k2Ai785RK_3dy_jSTJ_epiOb-aJozKPicxlRTjNQKS0AMM0Y6k1Rhsmc0FoaaUoGbdQFSmXpuS6MLzIoOCVYDZLDRuiZO8bdtB2RrXebbX_Uo126m-17hUoLrI-e89f7fmmaw8wJeqnTXVoU-3b_Hd3IcLngdd-rUTOcq4mi3f1zG_FYjZ7VG_sG5XxfYo</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>MacDonald, Michael R.</creator><creator>Petrie, Mark C.</creator><creator>Varyani, Fumi</creator><creator>Östergren, Jan</creator><creator>Michelson, Eric L.</creator><creator>Young, James B.</creator><creator>Solomon, Scott D.</creator><creator>Granger, Christopher B.</creator><creator>Swedberg, Karl</creator><creator>Yusuf, Salim</creator><creator>Pfeffer, Marc A.</creator><creator>McMurray, John J.V.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20080601</creationdate><title>Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure</title><author>MacDonald, Michael R. ; Petrie, Mark C. ; Varyani, Fumi ; Östergren, Jan ; Michelson, Eric L. ; Young, James B. ; Solomon, Scott D. ; Granger, Christopher B. ; Swedberg, Karl ; Yusuf, Salim ; Pfeffer, Marc A. ; McMurray, John J.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i197t-979d0514e6218eb3a332fbbab397601cf96c35fed8259bc5a8b584e85d63f42b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Diabetes</topic><topic>Heart failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MacDonald, Michael R.</creatorcontrib><creatorcontrib>Petrie, Mark C.</creatorcontrib><creatorcontrib>Varyani, Fumi</creatorcontrib><creatorcontrib>Östergren, Jan</creatorcontrib><creatorcontrib>Michelson, Eric L.</creatorcontrib><creatorcontrib>Young, James B.</creatorcontrib><creatorcontrib>Solomon, Scott D.</creatorcontrib><creatorcontrib>Granger, Christopher B.</creatorcontrib><creatorcontrib>Swedberg, Karl</creatorcontrib><creatorcontrib>Yusuf, Salim</creatorcontrib><creatorcontrib>Pfeffer, Marc A.</creatorcontrib><creatorcontrib>McMurray, John J.V.</creatorcontrib><collection>Istex</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MacDonald, Michael R.</au><au>Petrie, Mark C.</au><au>Varyani, Fumi</au><au>Östergren, Jan</au><au>Michelson, Eric L.</au><au>Young, James B.</au><au>Solomon, Scott D.</au><au>Granger, Christopher B.</au><au>Swedberg, Karl</au><au>Yusuf, Salim</au><au>Pfeffer, Marc A.</au><au>McMurray, John J.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure</atitle><jtitle>European heart journal</jtitle><date>2008-06-01</date><risdate>2008</risdate><volume>29</volume><issue>11</issue><spage>1377</spage><epage>1385</epage><pages>1377-1385</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims To determine whether the risk of adverse cardiovascular (CV) outcomes associated with diabetes differs in patients with low and preserved ejection fraction (EF) heart failure (HF). Methods and results We analysed outcomes in the Candesartan in Heart failure—Assessment of Reduction in Mortality and morbidity (CHARM) programme which randomized 7599 patients with symptomatic HF and a broad range of EF. The prevalence of diabetes was 28.3% in patients with preserved EF (&gt;40%) and 28.5% in those with low EF (≤40%). Diabetes was associated with a greater relative risk of CV death or HF hospitalization in patients with preserved EF [hazard ratio (HR) 2.0 (1.70–2.36)] than in patients with low EF [HR 1.60 (1.44–1.77); interaction test P = 0.0009]. For all-cause mortality, the risk conferred by diabetes was similar in both low and preserved EF groups. The effect of candesartan in reducing CV morbidity and mortality outcomes was not modified by having diabetes at baseline (P = 0.09 test for interaction). Conclusion Diabetes was an independent predictor of CV morbidity and mortality in patients with HF, regardless of EF. The relative risk of CV death or HF hospitalization conferred by diabetes was significantly greater in patients with preserved when compared with those with low EF HF.</abstract><pub>Oxford University Press</pub><doi>10.1093/eurheartj/ehn153</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0195-668X
ispartof European heart journal, 2008-06, Vol.29 (11), p.1377-1385
issn 0195-668X
1522-9645
language eng
recordid cdi_swepub_primary_oai_swepub_ki_se_564861
source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Diabetes
Heart failure
title Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A46%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-oup_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20diabetes%20on%20outcomes%20in%20patients%20with%20low%20and%20preserved%20ejection%20fraction%20heart%20failure&rft.jtitle=European%20heart%20journal&rft.au=MacDonald,%20Michael%20R.&rft.date=2008-06-01&rft.volume=29&rft.issue=11&rft.spage=1377&rft.epage=1385&rft.pages=1377-1385&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/eurheartj/ehn153&rft_dat=%3Coup_swepu%3E10.1093/eurheartj/ehn153%3C/oup_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_oup_id=10.1093/eurheartj/ehn153&rfr_iscdi=true