Collaborative Pooled Analysis of Data on C-Reactive Protein Gene Variants and Coronary Disease: Judging Causality by Mendelian Randomisation
Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associate...
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| Veröffentlicht in: | European journal of epidemiology 2008, Vol.23 (8), p.531-540 |
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| creator | CRP CHD Genetics Collaboration Danesh, J Hingorani, A ----------, ---- Hallmans, Göran |
| description | Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis. |
| doi_str_mv | 10.1007/s10654-008-9249-z |
| format | Article |
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Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/s10654-008-9249-z</identifier><identifier>PMID: 18425592</identifier><identifier>CODEN: EJEPE8</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Alleles ; Beräkningsmatematik ; Biological and medical sciences ; Blood tests ; C-Reactive Protein ; C-Reactive Protein - genetics ; C-Reactive Protein - metabolism ; Cardiology ; Cardiology. Vascular system ; Cardiovascular Disease ; Cardiovascular diseases ; Case-Control Studies ; Computational Mathematics ; Congenital heart defects ; Cooperative Behavior ; Coronary artery disease ; Coronary Disease ; Coronary Disease - epidemiology ; Coronary Disease - genetics ; Coronary heart disease ; Epidemiology ; General aspects ; Genetic ; Genetics ; Genotypes ; Haplotypes ; Heart ; Humans ; Infectious Diseases ; Inflammation ; Inflammation - genetics ; Medical Genetics ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicinsk genetik ; metabolism ; Miscellaneous ; Oncology ; Polymorphism ; Polymorphism, Genetic - genetics ; Predisposing factors ; Prospective studies ; Proteins ; Public Health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Research Design ; Risk factors</subject><ispartof>European journal of epidemiology, 2008, Vol.23 (8), p.531-540</ispartof><rights>Copyright 2008 Springer</rights><rights>Springer Science+Business Media B.V. 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-5ce237dbb5f8ffb0b3eaaaa9f50076afcf4a616ba94eb2dd18a09320d3b6d36f3</citedby><cites>FETCH-LOGICAL-c565t-5ce237dbb5f8ffb0b3eaaaa9f50076afcf4a616ba94eb2dd18a09320d3b6d36f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40283965$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40283965$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,4010,27904,27905,27906,41469,42538,51300,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20519183$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18425592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10468$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/113460$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:117328146$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>CRP CHD Genetics Collaboration</creatorcontrib><creatorcontrib>Danesh, J</creatorcontrib><creatorcontrib>Hingorani, A</creatorcontrib><creatorcontrib>----------, ----</creatorcontrib><creatorcontrib>Hallmans, Göran</creatorcontrib><creatorcontrib>CRP CHD Genetics Collaboration</creatorcontrib><creatorcontrib>CRP CHD Genetics Collaboration</creatorcontrib><title>Collaborative Pooled Analysis of Data on C-Reactive Protein Gene Variants and Coronary Disease: Judging Causality by Mendelian Randomisation</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><addtitle>Eur J Epidemiol</addtitle><description>Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.</description><subject>Alleles</subject><subject>Beräkningsmatematik</subject><subject>Biological and medical sciences</subject><subject>Blood tests</subject><subject>C-Reactive Protein</subject><subject>C-Reactive Protein - genetics</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Disease</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Computational Mathematics</subject><subject>Congenital heart defects</subject><subject>Cooperative Behavior</subject><subject>Coronary artery disease</subject><subject>Coronary Disease</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - genetics</subject><subject>Coronary heart disease</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Genetic</subject><subject>Genetics</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Heart</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Inflammation</subject><subject>Inflammation - genetics</subject><subject>Medical Genetics</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicinsk genetik</subject><subject>metabolism</subject><subject>Miscellaneous</subject><subject>Oncology</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Predisposing factors</subject><subject>Prospective studies</subject><subject>Proteins</subject><subject>Public Health</subject><subject>Public health. 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Vascular system</topic><topic>Cardiovascular Disease</topic><topic>Cardiovascular diseases</topic><topic>Case-Control Studies</topic><topic>Computational Mathematics</topic><topic>Congenital heart defects</topic><topic>Cooperative Behavior</topic><topic>Coronary artery disease</topic><topic>Coronary Disease</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - genetics</topic><topic>Coronary heart disease</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>Genetic</topic><topic>Genetics</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Heart</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Inflammation</topic><topic>Inflammation - genetics</topic><topic>Medical Genetics</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicinsk genetik</topic><topic>metabolism</topic><topic>Miscellaneous</topic><topic>Oncology</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Predisposing factors</topic><topic>Prospective studies</topic><topic>Proteins</topic><topic>Public Health</topic><topic>Public health. 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Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>18425592</pmid><doi>10.1007/s10654-008-9249-z</doi><tpages>10</tpages></addata></record> |
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| ispartof | European journal of epidemiology, 2008, Vol.23 (8), p.531-540 |
| issn | 0393-2990 1573-7284 |
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| source | MEDLINE; Jstor Complete Legacy; Springer Nature - Complete Springer Journals |
| subjects | Alleles Beräkningsmatematik Biological and medical sciences Blood tests C-Reactive Protein C-Reactive Protein - genetics C-Reactive Protein - metabolism Cardiology Cardiology. Vascular system Cardiovascular Disease Cardiovascular diseases Case-Control Studies Computational Mathematics Congenital heart defects Cooperative Behavior Coronary artery disease Coronary Disease Coronary Disease - epidemiology Coronary Disease - genetics Coronary heart disease Epidemiology General aspects Genetic Genetics Genotypes Haplotypes Heart Humans Infectious Diseases Inflammation Inflammation - genetics Medical Genetics Medical sciences Medicine Medicine & Public Health Medicinsk genetik metabolism Miscellaneous Oncology Polymorphism Polymorphism, Genetic - genetics Predisposing factors Prospective studies Proteins Public Health Public health. Hygiene Public health. Hygiene-occupational medicine Research Design Risk factors |
| title | Collaborative Pooled Analysis of Data on C-Reactive Protein Gene Variants and Coronary Disease: Judging Causality by Mendelian Randomisation |
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