Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Tumor hypoxia is linked to increased metastatic potential, but the molecular mechanisms coupling hypoxia to metastasis are poorly understood. Here, we show that Notch signaling is required to convert the hypoxic stimulus into epithelial-mesenchymal transition (EMT), increased motility, and invasiven...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-04, Vol.105 (17), p.6392-6397
Hauptverfasser:	Sahlgren, Cecilia, Gustafsson, Maria V, Jin, Shaobo, Poellinger, Lorenz, Lendahl, Urban
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cadherins Cadherins - genetics Cancer Cell adhesion & migration Cell Hypoxia Cell Line, Tumor Cell Movement Down regulation Down-Regulation - genetics Epithelium - pathology Extracellular Matrix Proteins - metabolism Gene Expression Regulation, Neoplastic Humans Hypoxia Ligands Mesoderm - pathology Messenger RNA Metastasis Neoplasm Invasiveness - pathology Neoplasms - genetics Neoplasms - pathology Proteins Receptors, Notch - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Snail Family Transcription Factors T lymphocytes Transcription Factors - genetics Transcription Factors - metabolism Tumors Up regulation Up-Regulation - genetics
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