Zinc Binding Catalytic Domain of Human Tankyrase 1

Tankyrases are recently discovered proteins implicated in many important functions in the cell including telomere homeostasis and mitosis. Tankyrase modulates the activity of target proteins through poly(ADP-ribosyl)ation, and here we report the structure of the catalytic poly(ADP-ribose) polymerase...

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Veröffentlicht in:	Journal of molecular biology 2008-05, Vol.379 (1), p.136-145
Hauptverfasser:	Lehtiö, Lari, Collins, Ruairi, van den Berg, Susanne, Johansson, Andreas, Dahlgren, Lars-Göran, Hammarström, Martin, Helleday, Thomas, Holmberg-Schiavone, Lovisa, Karlberg, Tobias, Weigelt, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Binding Sites Catalytic Domain Drug Design Enzyme Inhibitors - chemistry Humans inhibitor design Molecular Sequence Data Molecular Structure poly(ADP-ribose) polymerase tankyrase Tankyrases - chemistry zinc Zinc - chemistry
Online-Zugang:	Volltext
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