FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity

Fibroblast growth factor 21 (FGF21) is active in murine adipocytes and has beneficial metabolic effects in animal models of type 2 diabetes mellitus. We assessed whether FGF21 influences lipolysis in human adipocytes and 3T3-L1 cells. FGF21 had no short-time effect (h) while a 3-day incubation with...

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Veröffentlicht in:	FEBS letters 2008-05, Vol.582 (12), p.1725-1730
Hauptverfasser:	Arner, Peter, Pettersson, Amanda, Mitchell, Pamela J., Dunbar, James D., Kharitonenkov, Alexei, Rydén, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocyte Adipocytes - drug effects Adipocytes - metabolism Adipogenesis Animals ANP atrial natriuretic peptide Carrier Proteins Cell Differentiation - drug effects Differentiation Fatty Acids - blood Fatty Acids - metabolism Fibroblast Growth Factors - pharmacology Fibroblast Growth Factors - physiology Gene Expression - drug effects Glucuronidase - metabolism hormone sensitive lipase HSL Humans Insulin Resistance Lipolysis Lipolysis - drug effects Lipolysis - genetics Mice noradrenaline PDE3B Perilipin Perilipin-1 peroxisome proliferators-activated receptor gamma phosphodiesterase 3B Phosphoproteins - genetics Phosphoproteins - metabolism PKA PLIN PPARγ protein kinase A qRT-PCR quantitative reverse-transcribed polymerase chain reaction β-Klotho
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