Changes of Hypertonic Saline–Induced Masseter Muscle Pain Characteristics, by an Infusion of the Serotonin Receptor Type 3 Antagonist Granisetron

Abstract This study aimed to investigate whether granisetron reduces masseter muscle pain and allodynia induced by hypertonic saline. Fifteen healthy women and 15 age-matched healthy men participated in this randomized, placebo-controlled, double-blinded study. They first received bilateral injectio...

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Veröffentlicht in:	The journal of pain 2008-10, Vol.9 (10), p.892-901
Hauptverfasser:	Christidis, Nikolaos, Ioannidou, Kiriaki, Milosevic, Milena, Segerdahl, Märta, Ernberg, Malin
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 3-receptor Adult Anesthesia & Perioperative Care Double-Blind Method experimental muscle pain Facial Pain - chemically induced Facial Pain - drug therapy Female Granisetron Granisetron - administration & dosage Granisetron - therapeutic use Humans Injections, Intramuscular Male masseter muscle Masseter Muscle - drug effects Masseter Muscle - innervation Masseter Muscle - physiopathology Medicin och hälsovetenskap Pain Measurement - drug effects Pain Measurement - methods Pain Medicine pain threshold Pain Threshold - drug effects Pain Threshold - physiology Saline Solution, Hypertonic - administration & dosage Saline Solution, Hypertonic - adverse effects Serotonin 5-HT3 Receptor Antagonists Serotonin Antagonists - administration & dosage Serotonin Antagonists - therapeutic use sex difference Treatment Outcome Young Adult
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