Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes
Gene expression of carbonyl-metabolizing enzymes (CMEs) was investigated in normal buccal keratinocytes (NBK) and the transformed buccal keratinocyte lines SVpgC2a and SqCC/Y1. Studies were performed at a serum concentration known to induce terminal squamous differentiation (TSD) in normal cells. Ov...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2008-11, Vol.65 (22), p.3653-3663 |
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| creator | Staab, C. A Ceder, R Roberg, K Grafström, R. C Höög, J.-O |
| description | Gene expression of carbonyl-metabolizing enzymes (CMEs) was investigated in normal buccal keratinocytes (NBK) and the transformed buccal keratinocyte lines SVpgC2a and SqCC/Y1. Studies were performed at a serum concentration known to induce terminal squamous differentiation (TSD) in normal cells. Overall, 39 of 58 evaluated CMEs were found to be expressed at the transcript level. Together the transformed cell lines showed altered transcription of eight CME genes compared to NBK, substantiating earlier results. Serum increased transcript levels of ALDH1A3, DHRS3, HPGD and AKR1A1, and decreased those of ALDH4A1 in NBK; of these, the transformed, TSD-deficient cell lines partly retained regulation of ALDH1A3 and DHRS3. Activity measurements in crude cell lysates, including relevant enzymatic inhibitors, indicated significant capacity for CME-mediated xenobiotic metabolism among the cell lines, notably with an increase in serum-differentiated NBK. The results constitute the first evidence for differential CME gene expression and activity in non-differentiated and differentiated states of epithelial cells. |
| doi_str_mv | 10.1007/s00018-008-8554-8 |
| format | Article |
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A ; Ceder, R ; Roberg, K ; Grafström, R. C ; Höög, J.-O</creator><creatorcontrib>Staab, C. A ; Ceder, R ; Roberg, K ; Grafström, R. C ; Höög, J.-O</creatorcontrib><description>Gene expression of carbonyl-metabolizing enzymes (CMEs) was investigated in normal buccal keratinocytes (NBK) and the transformed buccal keratinocyte lines SVpgC2a and SqCC/Y1. Studies were performed at a serum concentration known to induce terminal squamous differentiation (TSD) in normal cells. Overall, 39 of 58 evaluated CMEs were found to be expressed at the transcript level. Together the transformed cell lines showed altered transcription of eight CME genes compared to NBK, substantiating earlier results. Serum increased transcript levels of ALDH1A3, DHRS3, HPGD and AKR1A1, and decreased those of ALDH4A1 in NBK; of these, the transformed, TSD-deficient cell lines partly retained regulation of ALDH1A3 and DHRS3. Activity measurements in crude cell lysates, including relevant enzymatic inhibitors, indicated significant capacity for CME-mediated xenobiotic metabolism among the cell lines, notably with an increase in serum-differentiated NBK. The results constitute the first evidence for differential CME gene expression and activity in non-differentiated and differentiated states of epithelial cells.</description><identifier>ISSN: 1420-682X</identifier><identifier>ISSN: 1420-9071</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-008-8554-8</identifier><identifier>PMID: 18854940</identifier><language>eng</language><publisher>Basel: Basel : SP Birkhäuser Verlag Basel</publisher><subject>Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Buccal mucosa ; Carbonyl compounds ; carbonyl-metabolizing enzymes ; Cell Biology ; Cell Differentiation - physiology ; Cell Transformation, Neoplastic - metabolism ; Enzymes ; Gene expression ; Gene Expression Regulation, Enzymologic - physiology ; Humans ; Keratinocytes - enzymology ; Keratinocytes - metabolism ; Life Sciences ; MEDICIN ; MEDICINE ; Metabolism ; microarray ; Mouth Mucosa - cytology ; Mouth Mucosa - enzymology ; Oligonucleotide Array Sequence Analysis ; Oxidoreductases - blood ; Oxidoreductases - metabolism ; quinone metabolism ; Research Article ; serum effects ; terminal squamous differentiation ; xenobiotic metabolism</subject><ispartof>Cellular and molecular life sciences : CMLS, 2008-11, Vol.65 (22), p.3653-3663</ispartof><rights>Birkhaueser 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-19000d942edbca7e3b2079d1ef9ffb55f8ce8c05d031c914215884ff3296757f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131755/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131755/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18854940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16167$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:117896040$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Staab, C. A</creatorcontrib><creatorcontrib>Ceder, R</creatorcontrib><creatorcontrib>Roberg, K</creatorcontrib><creatorcontrib>Grafström, R. C</creatorcontrib><creatorcontrib>Höög, J.-O</creatorcontrib><title>Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Gene expression of carbonyl-metabolizing enzymes (CMEs) was investigated in normal buccal keratinocytes (NBK) and the transformed buccal keratinocyte lines SVpgC2a and SqCC/Y1. Studies were performed at a serum concentration known to induce terminal squamous differentiation (TSD) in normal cells. Overall, 39 of 58 evaluated CMEs were found to be expressed at the transcript level. Together the transformed cell lines showed altered transcription of eight CME genes compared to NBK, substantiating earlier results. Serum increased transcript levels of ALDH1A3, DHRS3, HPGD and AKR1A1, and decreased those of ALDH4A1 in NBK; of these, the transformed, TSD-deficient cell lines partly retained regulation of ALDH1A3 and DHRS3. Activity measurements in crude cell lysates, including relevant enzymatic inhibitors, indicated significant capacity for CME-mediated xenobiotic metabolism among the cell lines, notably with an increase in serum-differentiated NBK. The results constitute the first evidence for differential CME gene expression and activity in non-differentiated and differentiated states of epithelial cells.</description><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Buccal mucosa</subject><subject>Carbonyl compounds</subject><subject>carbonyl-metabolizing enzymes</subject><subject>Cell Biology</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Enzymes</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Enzymologic - physiology</subject><subject>Humans</subject><subject>Keratinocytes - enzymology</subject><subject>Keratinocytes - metabolism</subject><subject>Life Sciences</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>Metabolism</subject><subject>microarray</subject><subject>Mouth Mucosa - cytology</subject><subject>Mouth Mucosa - enzymology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oxidoreductases - blood</subject><subject>Oxidoreductases - metabolism</subject><subject>quinone metabolism</subject><subject>Research Article</subject><subject>serum effects</subject><subject>terminal squamous differentiation</subject><subject>xenobiotic metabolism</subject><issn>1420-682X</issn><issn>1420-9071</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kktv1TAQhSMEog_4AWwgYtEVAU8SJ_YKVeUpVWJRithZjjO-dZvYt3ZSuP31zNWNKEWClceeb459rJNlz4C9BsbaN4kxBqJgTBSC87oQD7J9qEtWSNbCw6VuRPl9LztI6ZJgLsrmcbYHQvBa1mw_uz7DOI9FxLQOPrkbzPHnmnbJBZ8Hmxsdu-A3QzHipLswuFvnVzn6282IKXc-9yGOesi17_Mpap8s7bHPL-ZR-7ybjaHmFUY9OR_MZsL0JHtk9ZDw6bIeZucf3n89-VScfvn4-eT4tDCc86kASeZ6WZfYd0a3WHUla2UPaKW1HedWGBSG8Z5VYCQ5JW-itrYqZdPy1laHWbHTTT9wPXdqHd2o40YF7dRydEUVKt5A2wLxr_7Jv3PfjlWIKzW4WUEDTUv42x1OLBk26Mn-cG_qfse7C7UKNwoAKmg5J4WjRSGG6xnTpEaXDA6D9hjmpEA2lZBcEPjyL_AyzNHT56kSKg61ZCVBsINMDClFtL-fAkxt06J2aVGUFrVNi9oKP__Tw93EEg8CyuVPqOVXGO9u_p_qi92Q1UHpVXRJnZ-VDCqKX1MxCdUvX2DYBg</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Staab, C. 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A</au><au>Ceder, R</au><au>Roberg, K</au><au>Grafström, R. C</au><au>Höög, J.-O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>65</volume><issue>22</issue><spage>3653</spage><epage>3663</epage><pages>3653-3663</pages><issn>1420-682X</issn><issn>1420-9071</issn><eissn>1420-9071</eissn><abstract>Gene expression of carbonyl-metabolizing enzymes (CMEs) was investigated in normal buccal keratinocytes (NBK) and the transformed buccal keratinocyte lines SVpgC2a and SqCC/Y1. Studies were performed at a serum concentration known to induce terminal squamous differentiation (TSD) in normal cells. Overall, 39 of 58 evaluated CMEs were found to be expressed at the transcript level. Together the transformed cell lines showed altered transcription of eight CME genes compared to NBK, substantiating earlier results. Serum increased transcript levels of ALDH1A3, DHRS3, HPGD and AKR1A1, and decreased those of ALDH4A1 in NBK; of these, the transformed, TSD-deficient cell lines partly retained regulation of ALDH1A3 and DHRS3. Activity measurements in crude cell lysates, including relevant enzymatic inhibitors, indicated significant capacity for CME-mediated xenobiotic metabolism among the cell lines, notably with an increase in serum-differentiated NBK. The results constitute the first evidence for differential CME gene expression and activity in non-differentiated and differentiated states of epithelial cells.</abstract><cop>Basel</cop><pub>Basel : SP Birkhäuser Verlag Basel</pub><pmid>18854940</pmid><doi>10.1007/s00018-008-8554-8</doi><tpages>11</tpages></addata></record> |
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| subjects | Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Buccal mucosa Carbonyl compounds carbonyl-metabolizing enzymes Cell Biology Cell Differentiation - physiology Cell Transformation, Neoplastic - metabolism Enzymes Gene expression Gene Expression Regulation, Enzymologic - physiology Humans Keratinocytes - enzymology Keratinocytes - metabolism Life Sciences MEDICIN MEDICINE Metabolism microarray Mouth Mucosa - cytology Mouth Mucosa - enzymology Oligonucleotide Array Sequence Analysis Oxidoreductases - blood Oxidoreductases - metabolism quinone metabolism Research Article serum effects terminal squamous differentiation xenobiotic metabolism |
| title | Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes |
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