Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype

Stem cell transplantation across HLA barriers may trigger NK cell-mediated graft-vs-leukemia effects leading to improved survival for patients with hematological malignancies. However, the genetic algorithm based on killer cell Ig-like receptor (KIR) and HLA genes used to predict NK cell alloreactiv...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-11, Vol.181 (9), p.6010-6019
Hauptverfasser:	Fauriat, Cyril, Andersson, Sandra, Bjorklund, Andreas T, Carlsten, Mattias, Schaffer, Marie, Bjorkstrom, Niklas K, Baumann, Bettina C, Michaelsson, Jakob, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Cytotoxicity Tests, Immunologic Genotype Graft vs Leukemia Effect - genetics Graft vs Leukemia Effect - immunology Haplotypes Histocompatibility Testing - methods HLA-A Antigens - metabolism HLA-A11 Antigen HLA-A3 Antigen - metabolism Homozygote Humans K562 Cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Medicin och hälsovetenskap NK Cell Lectin-Like Receptor Subfamily C - biosynthesis NK Cell Lectin-Like Receptor Subfamily C - genetics NK Cell Lectin-Like Receptor Subfamily C - immunology NK Cell Lectin-Like Receptor Subfamily C - metabolism Receptors, KIR3DL2 - biosynthesis Receptors, KIR3DL2 - genetics Receptors, KIR3DL2 - immunology Receptors, KIR3DL2 - metabolism Stem Cell Transplantation
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