Splicing Factors Facilitate RNAi-Directed Silencing in Fission Yeast

Heterochromatin formation at fission yeast centromeres is directed by RNA interference (RNAi). Noncoding transcripts derived from centromeric repeats are processed into small interfering RNAs (siRNAs) that direct the RNA-induced transcriptional silencing (RITS) effector complex to engage centromere...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2008-10, Vol.322 (5901), p.602-606
Hauptverfasser:	Bayne, Elizabeth H., Portoso, Manuela, Kagansky, Alexander, Kos-Braun, Isabelle C., Urano, Takeshi, Ekwall, Karl, Alves, Flavia, Rappsilber, Juri, Allshire, Robin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Biological and medical sciences Cellular biology Centromere - genetics Centromere - metabolism Centromeres Chromatin Fundamental and applied biological sciences. Psychology Genes, Fungal Genetic mutation Growth, nutrition, metabolism, transports, enzymes. Molecular biology Heterochromatin Heterochromatin - metabolism Histones - metabolism Methylation Microbiology Mutation Mycology Phosphoproteins - genetics Phosphoproteins - metabolism Plasmids Reverse transcriptase polymerase chain reaction Ribonucleic acid Ribonucleoprotein, U2 Small Nuclear - genetics Ribonucleoprotein, U2 Small Nuclear - metabolism RNA RNA Interference RNA Splicing RNA, Small Interfering - metabolism Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Small interfering RNA Spliceosomes - metabolism Splicing Yeast Yeasts
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