Alternative isoform regulation in human tissue transcriptomes

Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes on the basis of de...

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Veröffentlicht in:	Nature 2008-11, Vol.456 (7221), p.470-476
Hauptverfasser:	Burge, Christopher B, Wang, Eric T, Sandberg, Rickard, Luo, Shujun, Khrebtukova, Irina, Zhang, Lu, Mayr, Christine, Kingsmore, Stephen F, Schroth, Gary P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Base Sequence Biological and medical sciences Breast cancer Cell Line Cellular proteins Exons - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genetic aspects Humanities and Social Sciences Humans Medicin och hälsovetenskap Molecular and cellular biology Molecular genetics multidisciplinary Open Reading Frames - genetics Organ Specificity Physiological aspects Polyadenylation Protein Isoforms - genetics Proteins Repressor Proteins - metabolism RNA processing RNA Splicing Factors RNA, Messenger - analysis RNA, Messenger - genetics RNA-Binding Proteins - metabolism Science Science (multidisciplinary) Statistical methods Tissues Transcription. Transcription factor. Splicing. Rna processing
Online-Zugang:	Volltext
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