Inflammatory Interaction Between LIGHT and Proteinase-Activated Receptor-2 in Endothelial Cells: Potential Role in Atherogenesis

The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. We have previously reported that the tumor necrosis factor superfamily member LIGHT could be involved in atherogenesis through its ability to...

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Veröffentlicht in:	Circulation research 2009-01, Vol.104 (1), p.60-68
Hauptverfasser:	Sandberg, Wiggo J, Halvorsen, Bente, Yndestad, Arne, Smith, Camilla, Otterdal, Kari, Brosstad, Frank R, Frøland, Stig S, Olofsson, Peder S, Damås, Jan K, Gullestad, Lars, Hansson, Göran K, Øie, Erik, Aukrust, Pål
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angina Pectoris - metabolism Angina Pectoris - pathology Angina, Unstable - metabolism Angina, Unstable - pathology Animals Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured - metabolism Chemokine CCL2 - secretion Endothelial Cells - metabolism Endothelial Cells - pathology Endothelial Cells - secretion Endothelium, Vascular - pathology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Interleukin-8 - secretion JNK Mitogen-Activated Protein Kinases - physiology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Nitric Oxide Synthase Type III - metabolism Receptor, PAR-2 - agonists Receptor, PAR-2 - physiology Receptors, Tumor Necrosis Factor, Member 14 - physiology Recombinant Fusion Proteins - physiology Signal Transduction - physiology Tumor Necrosis Factor Ligand Superfamily Member 14 - genetics Tumor Necrosis Factor Ligand Superfamily Member 14 - physiology Vasculitis - complications Vasculitis - metabolism Vasculitis - pathology Vertebrates: cardiovascular system
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