Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites

Leukotriene D 4 (LTD 4)-induced bronchoconstriction in guinea-pig airways has a cyclooxygenase (COX)-dependent component. The main objective of this study was to establish if prostaglandin (PG) D 2-induced bronchoconstriction also was modulated by COX products. The effects of non-selective and selec...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2009-04, Vol.88 (3), p.101-110
Hauptverfasser:	Selg, Ewa, Andersson, Margareta, Låstbom, Lena, Ryrfeldt, Åke, Dahlén, Sven-Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology 6-Ketoprostaglandin F1 alpha - metabolism Airway smooth muscle Animals Bronchoconstriction - drug effects Bronchoconstrictor Agents - pharmacology Bronchodilator Agents - pharmacology Cyclooxygenase inhibitors Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase-1 Cyclooxygenase-2 Dinoprostone - pharmacology Epoprostenol - pharmacology Guinea Pigs Guinea-pig lung In Vitro Techniques Leukotriene D4 - pharmacology Lung - drug effects Male Prostaglandin D2 - pharmacology Prostaglandin-Endoperoxide Synthases - metabolism
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