Angiotensin II enhances the afferent arteriolar response to adenosine through increases in cytosolic calcium

Angiotensin II (Ang II) is a strong renal vasoconstrictor and modulates the tubuloglomerular feedback (TGF). We hypothesized that Ang II at low concentrations enhances the vasoconstrictor effect of adenosine (Ado), the mediator of TGF. Afferent arterioles of mice were isolated and perfused, and both...

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Veröffentlicht in:	Acta Physiologica 2009-08, Vol.196 (4), p.435-445
Hauptverfasser:	Lai, E.Y, Patzak, A, Persson, A.E.G, Carlström, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - administration & dosage Adenosine - physiology Adenosine A1 Receptor Antagonists Adenosine A2 Receptor Antagonists Angiotensin II - administration & dosage Angiotensin II - physiology Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Arterioles - chemistry Arterioles - drug effects Biological and medical sciences Calcium - chemistry Cytosol - chemistry Fundamental and applied biological sciences. Psychology Kidney - blood supply Kidney - chemistry Male MEDICIN Medicin och hälsovetenskap MEDICINE Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - chemistry Naphthyridines - pharmacology Purines - pharmacology Receptor, Adenosine A1 - metabolism Receptor, Angiotensin, Type 1 - metabolism Receptors, Adenosine A2 - metabolism renal arterioles Triazines - pharmacology Triazoles - pharmacology tubuloglomerular feedback vascular smooth muscle Vasoconstriction - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems
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