The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

Astrocytes in the CNS respond to tissue damage by becoming reactive. They migrate, undergo hypertrophy, and form a glial scar that inhibits axon regeneration. Therefore, limiting astrocytic responses represents a potential therapeutic strategy to improve functional recovery. It was recently shown th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2009-01, Vol.29 (4), p.1093-1104
Hauptverfasser:	Codeluppi, Simone, Svensson, Camilla I, Hefferan, Michael P, Valencia, Fatima, Silldorff, Morgan D, Oshiro, Masakatsu, Marsala, Martin, Pasquale, Elena B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Astrocytes - drug effects Astrocytes - metabolism Cells, Cultured Chromones - pharmacology Disease Models, Animal Enzyme Inhibitors - pharmacology Epidermal Growth Factor - drug effects Epidermal Growth Factor - genetics ErbB Receptors - genetics ErbB Receptors - metabolism Excitatory Amino Acid Transporter 2 - genetics Excitatory Amino Acid Transporter 2 - metabolism Flavonoids - pharmacology Glial Fibrillary Acidic Protein - metabolism Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Male Medicin och hälsovetenskap Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Morpholines - pharmacology Neuropeptides - genetics Neuropeptides - metabolism Protein Kinases - genetics Protein Kinases - metabolism Ras Homolog Enriched in Brain Protein Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Signal Transduction - physiology Sirolimus - pharmacology Sirolimus - therapeutic use Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology TOR Serine-Threonine Kinases Transcription Factors - genetics Transcription Factors - metabolism Transfection - methods Up-Regulation - drug effects Up-Regulation - physiology Vimentin - genetics Vimentin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!