Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia
Summary Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function. Aim To examine mast cell, eosinophil and intraep...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2009-04, Vol.29 (7), p.765-773 |
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| creator | WALKER, M. M. TALLEY, N. J. PRABHAKAR, M. PENNANEAC’H, C. J. ARO, P. RONKAINEN, J. STORSKRUBB, T. HARMSEN, W. S. ZINSMEISTER, A. R. AGREUS, L. |
| description | Summary
Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function.
Aim To examine mast cell, eosinophil and intraepithelial lymphocyte populations in duodenal biopsies of subjects with IBS and FD.
Methods A random sample of an adult Swedish population (n = 1001; mean age 54 years; 51% female) underwent upper endoscopy and biopsy; 51 cases with FD and 41 cases with IBS were compared with 48 randomly selected controls. Eosinophils were identified by light microscopy; mast cells by immunocytochemistry (CD117). Intraepithelial lymphocytes were counted per 100 enterocytes. Cell counts were quantified by counting the number per high power field (HPF) in 5HPFs in the bulb (D1) and second part of duodenum (D2), summed over 5HPFs at each site.
Results Cases and controls showed similar demographics. Compared to controls, IELs in IBS‐constipation were significantly increased (P = 0.005). Mast cells were significantly increased in IBS in D2 (P |
| doi_str_mv | 10.1111/j.1365-2036.2009.03937.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_559954</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733321320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6387-8f6671272b4c0f03f9f4bdfbd0f169355264451083a6dd0ae9aa35d9f96da9c23</originalsourceid><addsrcrecordid>eNqNks2O0zAUhS0EYobCKyBvgA0p_omdeAHSaPiVRoLFsLac-Jq648YhTunkVXhanLYUZoPwxpbvd46ufQ9CmJIlzevVekm5FAUjXC4ZIWpJuOLV8vYeOj8V7qNzwqQqWE35GXqU0poQIivCHqIzqmjNqSDn6OfbbbTQmYA3Jo2xncaYfHqJIW9d7Fc-eINNZ7HvxsFA78cV5KuAw7TpV795bBLuY0q-CYCtT2ASZMPhBoaUlTiLsB8GP5oZaOIOAk5TZ4e4gb2723bt6OPch51SD33y5jF64ExI8OS4L9DX9--uLz8WV58_fLq8uCpayeuqqJ2UFWUVa8qWOMKdcmVjXWOJo1JxIZgsS0FJzY20lhhQxnBhlVPSGtUyvkDFwTftoN82uh98bn3S0Xh9vLrJJ9BCKCXKzL858LmyAdvC_DPhjuxupfMr_S3-0CWpiNwbvDgaDPH7FtKoNz61EILpIG6TrjjnjPI8xAV6_k-SEVHmiYoM1gewHfIYBnCndijRc2T0Ws_J0HMy9BwZvY-Mvs3Sp38_54_wmJEMPDsCJrUmuMF0rU8njlFGa5G_d4FeH7idDzD9dwP64sv1fOK_AIST4vo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20547025</pqid></control><display><type>article</type><title>Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><creator>WALKER, M. M. ; TALLEY, N. J. ; PRABHAKAR, M. ; PENNANEAC’H, C. J. ; ARO, P. ; RONKAINEN, J. ; STORSKRUBB, T. ; HARMSEN, W. S. ; ZINSMEISTER, A. R. ; AGREUS, L.</creator><creatorcontrib>WALKER, M. M. ; TALLEY, N. J. ; PRABHAKAR, M. ; PENNANEAC’H, C. J. ; ARO, P. ; RONKAINEN, J. ; STORSKRUBB, T. ; HARMSEN, W. S. ; ZINSMEISTER, A. R. ; AGREUS, L.</creatorcontrib><description>Summary
Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function.
Aim To examine mast cell, eosinophil and intraepithelial lymphocyte populations in duodenal biopsies of subjects with IBS and FD.
Methods A random sample of an adult Swedish population (n = 1001; mean age 54 years; 51% female) underwent upper endoscopy and biopsy; 51 cases with FD and 41 cases with IBS were compared with 48 randomly selected controls. Eosinophils were identified by light microscopy; mast cells by immunocytochemistry (CD117). Intraepithelial lymphocytes were counted per 100 enterocytes. Cell counts were quantified by counting the number per high power field (HPF) in 5HPFs in the bulb (D1) and second part of duodenum (D2), summed over 5HPFs at each site.
Results Cases and controls showed similar demographics. Compared to controls, IELs in IBS‐constipation were significantly increased (P = 0.005). Mast cells were significantly increased in IBS in D2 (P < 0.001), while eosinophils were significantly increased in FD in D1 and D2 (P < 0.001).
Conclusion Duodenal mast cell hyperplasia is linked to IBS and eosinophilia to FD, and duodenal biopsy may identify subsets of these disorders.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2009.03937.x</identifier><identifier>PMID: 19183150</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Biomarkers - metabolism ; Case-Control Studies ; Digestive system ; Duodenal Diseases - pathology ; Dyspepsia - immunology ; Dyspepsia - pathology ; Dyspepsia - physiopathology ; Eosinophilia - immunology ; Eosinophilia - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; Intestinal Mucosa - immunology ; Intestinal Mucosa - pathology ; Intestinal Mucosa - physiopathology ; Irritable Bowel Syndrome - immunology ; Irritable Bowel Syndrome - pathology ; Irritable Bowel Syndrome - physiopathology ; Lymphocytosis - immunology ; Lymphocytosis - pathology ; Male ; Mastocytosis - immunology ; Mastocytosis - pathology ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Alimentary pharmacology & therapeutics, 2009-04, Vol.29 (7), p.765-773</ispartof><rights>2009 Blackwell Publishing Ltd</rights><rights>2009 INIST-CNRS</rights><rights>2009 Blackwell Publishing Ltd 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6387-8f6671272b4c0f03f9f4bdfbd0f169355264451083a6dd0ae9aa35d9f96da9c23</citedby><cites>FETCH-LOGICAL-c6387-8f6671272b4c0f03f9f4bdfbd0f169355264451083a6dd0ae9aa35d9f96da9c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2009.03937.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2009.03937.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21218508$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19183150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118385883$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>WALKER, M. M.</creatorcontrib><creatorcontrib>TALLEY, N. J.</creatorcontrib><creatorcontrib>PRABHAKAR, M.</creatorcontrib><creatorcontrib>PENNANEAC’H, C. J.</creatorcontrib><creatorcontrib>ARO, P.</creatorcontrib><creatorcontrib>RONKAINEN, J.</creatorcontrib><creatorcontrib>STORSKRUBB, T.</creatorcontrib><creatorcontrib>HARMSEN, W. S.</creatorcontrib><creatorcontrib>ZINSMEISTER, A. R.</creatorcontrib><creatorcontrib>AGREUS, L.</creatorcontrib><title>Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function.
Aim To examine mast cell, eosinophil and intraepithelial lymphocyte populations in duodenal biopsies of subjects with IBS and FD.
Methods A random sample of an adult Swedish population (n = 1001; mean age 54 years; 51% female) underwent upper endoscopy and biopsy; 51 cases with FD and 41 cases with IBS were compared with 48 randomly selected controls. Eosinophils were identified by light microscopy; mast cells by immunocytochemistry (CD117). Intraepithelial lymphocytes were counted per 100 enterocytes. Cell counts were quantified by counting the number per high power field (HPF) in 5HPFs in the bulb (D1) and second part of duodenum (D2), summed over 5HPFs at each site.
Results Cases and controls showed similar demographics. Compared to controls, IELs in IBS‐constipation were significantly increased (P = 0.005). Mast cells were significantly increased in IBS in D2 (P < 0.001), while eosinophils were significantly increased in FD in D1 and D2 (P < 0.001).
Conclusion Duodenal mast cell hyperplasia is linked to IBS and eosinophilia to FD, and duodenal biopsy may identify subsets of these disorders.</description><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Case-Control Studies</subject><subject>Digestive system</subject><subject>Duodenal Diseases - pathology</subject><subject>Dyspepsia - immunology</subject><subject>Dyspepsia - pathology</subject><subject>Dyspepsia - physiopathology</subject><subject>Eosinophilia - immunology</subject><subject>Eosinophilia - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - physiopathology</subject><subject>Irritable Bowel Syndrome - immunology</subject><subject>Irritable Bowel Syndrome - pathology</subject><subject>Irritable Bowel Syndrome - physiopathology</subject><subject>Lymphocytosis - immunology</subject><subject>Lymphocytosis - pathology</subject><subject>Male</subject><subject>Mastocytosis - immunology</subject><subject>Mastocytosis - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNks2O0zAUhS0EYobCKyBvgA0p_omdeAHSaPiVRoLFsLac-Jq648YhTunkVXhanLYUZoPwxpbvd46ufQ9CmJIlzevVekm5FAUjXC4ZIWpJuOLV8vYeOj8V7qNzwqQqWE35GXqU0poQIivCHqIzqmjNqSDn6OfbbbTQmYA3Jo2xncaYfHqJIW9d7Fc-eINNZ7HvxsFA78cV5KuAw7TpV795bBLuY0q-CYCtT2ASZMPhBoaUlTiLsB8GP5oZaOIOAk5TZ4e4gb2723bt6OPch51SD33y5jF64ExI8OS4L9DX9--uLz8WV58_fLq8uCpayeuqqJ2UFWUVa8qWOMKdcmVjXWOJo1JxIZgsS0FJzY20lhhQxnBhlVPSGtUyvkDFwTftoN82uh98bn3S0Xh9vLrJJ9BCKCXKzL858LmyAdvC_DPhjuxupfMr_S3-0CWpiNwbvDgaDPH7FtKoNz61EILpIG6TrjjnjPI8xAV6_k-SEVHmiYoM1gewHfIYBnCndijRc2T0Ws_J0HMy9BwZvY-Mvs3Sp38_54_wmJEMPDsCJrUmuMF0rU8njlFGa5G_d4FeH7idDzD9dwP64sv1fOK_AIST4vo</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>WALKER, M. M.</creator><creator>TALLEY, N. J.</creator><creator>PRABHAKAR, M.</creator><creator>PENNANEAC’H, C. J.</creator><creator>ARO, P.</creator><creator>RONKAINEN, J.</creator><creator>STORSKRUBB, T.</creator><creator>HARMSEN, W. S.</creator><creator>ZINSMEISTER, A. R.</creator><creator>AGREUS, L.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>200904</creationdate><title>Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia</title><author>WALKER, M. M. ; TALLEY, N. J. ; PRABHAKAR, M. ; PENNANEAC’H, C. J. ; ARO, P. ; RONKAINEN, J. ; STORSKRUBB, T. ; HARMSEN, W. S. ; ZINSMEISTER, A. R. ; AGREUS, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6387-8f6671272b4c0f03f9f4bdfbd0f169355264451083a6dd0ae9aa35d9f96da9c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Case-Control Studies</topic><topic>Digestive system</topic><topic>Duodenal Diseases - pathology</topic><topic>Dyspepsia - immunology</topic><topic>Dyspepsia - pathology</topic><topic>Dyspepsia - physiopathology</topic><topic>Eosinophilia - immunology</topic><topic>Eosinophilia - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - physiopathology</topic><topic>Irritable Bowel Syndrome - immunology</topic><topic>Irritable Bowel Syndrome - pathology</topic><topic>Irritable Bowel Syndrome - physiopathology</topic><topic>Lymphocytosis - immunology</topic><topic>Lymphocytosis - pathology</topic><topic>Male</topic><topic>Mastocytosis - immunology</topic><topic>Mastocytosis - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WALKER, M. M.</creatorcontrib><creatorcontrib>TALLEY, N. J.</creatorcontrib><creatorcontrib>PRABHAKAR, M.</creatorcontrib><creatorcontrib>PENNANEAC’H, C. J.</creatorcontrib><creatorcontrib>ARO, P.</creatorcontrib><creatorcontrib>RONKAINEN, J.</creatorcontrib><creatorcontrib>STORSKRUBB, T.</creatorcontrib><creatorcontrib>HARMSEN, W. S.</creatorcontrib><creatorcontrib>ZINSMEISTER, A. R.</creatorcontrib><creatorcontrib>AGREUS, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WALKER, M. M.</au><au>TALLEY, N. J.</au><au>PRABHAKAR, M.</au><au>PENNANEAC’H, C. J.</au><au>ARO, P.</au><au>RONKAINEN, J.</au><au>STORSKRUBB, T.</au><au>HARMSEN, W. S.</au><au>ZINSMEISTER, A. R.</au><au>AGREUS, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2009-04</date><risdate>2009</risdate><volume>29</volume><issue>7</issue><spage>765</spage><epage>773</epage><pages>765-773</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function.
Aim To examine mast cell, eosinophil and intraepithelial lymphocyte populations in duodenal biopsies of subjects with IBS and FD.
Methods A random sample of an adult Swedish population (n = 1001; mean age 54 years; 51% female) underwent upper endoscopy and biopsy; 51 cases with FD and 41 cases with IBS were compared with 48 randomly selected controls. Eosinophils were identified by light microscopy; mast cells by immunocytochemistry (CD117). Intraepithelial lymphocytes were counted per 100 enterocytes. Cell counts were quantified by counting the number per high power field (HPF) in 5HPFs in the bulb (D1) and second part of duodenum (D2), summed over 5HPFs at each site.
Results Cases and controls showed similar demographics. Compared to controls, IELs in IBS‐constipation were significantly increased (P = 0.005). Mast cells were significantly increased in IBS in D2 (P < 0.001), while eosinophils were significantly increased in FD in D1 and D2 (P < 0.001).
Conclusion Duodenal mast cell hyperplasia is linked to IBS and eosinophilia to FD, and duodenal biopsy may identify subsets of these disorders.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19183150</pmid><doi>10.1111/j.1365-2036.2009.03937.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online |
| subjects | Biological and medical sciences Biomarkers - metabolism Case-Control Studies Digestive system Duodenal Diseases - pathology Dyspepsia - immunology Dyspepsia - pathology Dyspepsia - physiopathology Eosinophilia - immunology Eosinophilia - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestinal Mucosa - physiopathology Irritable Bowel Syndrome - immunology Irritable Bowel Syndrome - pathology Irritable Bowel Syndrome - physiopathology Lymphocytosis - immunology Lymphocytosis - pathology Male Mastocytosis - immunology Mastocytosis - pathology Medical sciences Middle Aged Other diseases. Semiology Pharmacology. Drug treatments Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia |
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