Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden
Abstract Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the M...
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| description | Abstract Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of 40,228 hospitalized cases were identified of which 3006 were affected sibling pairs. The overall significant familial SIRs were 4.82 for psychotic disorders and 7.34 for schizophrenia. The highest SIRs were found in the younger ages. There were no significant gender differences. The significant SIR for psychotic disorders among twin pairs was 6.40 and the significant SIRs for psychotic disorders among spouses varied between 3.17 and 3.29. Age difference between siblings had no effect on the magnitude of the SIRs. The findings of the present large-scale study suggest that heritable factors have a stronger effect on psychotic disorders and schizophrenia than environmental factors. Future studies could coordinate epidemiological studies of large populations with molecular biology resources. |
| doi_str_mv | 10.1016/j.psychres.2007.12.003 |
| format | Article |
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However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of 40,228 hospitalized cases were identified of which 3006 were affected sibling pairs. The overall significant familial SIRs were 4.82 for psychotic disorders and 7.34 for schizophrenia. The highest SIRs were found in the younger ages. There were no significant gender differences. The significant SIR for psychotic disorders among twin pairs was 6.40 and the significant SIRs for psychotic disorders among spouses varied between 3.17 and 3.29. Age difference between siblings had no effect on the magnitude of the SIRs. The findings of the present large-scale study suggest that heritable factors have a stronger effect on psychotic disorders and schizophrenia than environmental factors. Future studies could coordinate epidemiological studies of large populations with molecular biology resources.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2007.12.003</identifier><identifier>PMID: 19208442</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age Factors ; Aged ; Biological and medical sciences ; Cross-Sectional Studies ; Familial aggregation ; Female ; Genetic Predisposition to Disease - genetics ; Heritability ; Hospitalization - statistics & numerical data ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Population-based ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic Disorders - epidemiology ; Psychotic Disorders - genetics ; Registries ; Schizophrenia ; Schizophrenia - epidemiology ; Schizophrenia - genetics ; Sex Factors ; Sibling risk ; Siblings ; Social Environment ; Sweden ; Young Adult</subject><ispartof>Psychiatry research, 2009-03, Vol.166 (1), p.1-6</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-35857db7323b218ab4e6b379712ee779328da5d9a06c07b9140314e1b2d3f4a03</citedby><cites>FETCH-LOGICAL-c592t-35857db7323b218ab4e6b379712ee779328da5d9a06c07b9140314e1b2d3f4a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psychres.2007.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,552,780,784,885,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21496039$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19208442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118520010$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xinjun</creatorcontrib><creatorcontrib>Sundquist, Jan</creatorcontrib><creatorcontrib>Hemminki, Kari</creatorcontrib><creatorcontrib>Sundquist, Kristina</creatorcontrib><title>Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of 40,228 hospitalized cases were identified of which 3006 were affected sibling pairs. The overall significant familial SIRs were 4.82 for psychotic disorders and 7.34 for schizophrenia. The highest SIRs were found in the younger ages. There were no significant gender differences. The significant SIR for psychotic disorders among twin pairs was 6.40 and the significant SIRs for psychotic disorders among spouses varied between 3.17 and 3.29. Age difference between siblings had no effect on the magnitude of the SIRs. The findings of the present large-scale study suggest that heritable factors have a stronger effect on psychotic disorders and schizophrenia than environmental factors. Future studies could coordinate epidemiological studies of large populations with molecular biology resources.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Familial aggregation</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Heritability</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Population-based</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Psychotic Disorders - genetics</subject><subject>Registries</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><subject>Sex Factors</subject><subject>Sibling risk</subject><subject>Siblings</subject><subject>Social Environment</subject><subject>Sweden</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFkk9vEzEQxVcIREvhK1S-wC3Bf3bX60sFqiggVeJQOFtee5JMsrGDZ9Mq_fQ4TSiUCydbnt-8N9abqjoXfCq4aN8vpxva-UUGmkrO9VTIKefqWXUqOi0nWkj1vDotYDMRuhMn1SuiJedcCmNeVifCSN7VtTytlldujQO6gWWkFbE0Yw_CaUTPAlLKATIxFwMjv8D7tCmeER1z6xTnjLAfMM6J9Y4gsBTZItEGRzfgvRsxRWIY2c0dBIivqxczNxC8OZ5n1Y-rT98vv0yuv33-evnxeuIbI8eJarpGh14rqXopOtfX0PZKm_InAK2Nkl1wTTCOt57r3oiaK1GD6GVQs9pxdVZNDrp0B5ttbzcZ1y7vbHJoj0-rcgPbNEbXbeEvDnyprCF4iGN2w5O2p5WICztPt1a2pm25KgLvjgI5_dwCjXaN5GEYXIS0JdsWruZdU8D2APqciDLMHk0Et_tY7dL-jtXuY7VCWv7gcP73iH_ajjkW4O0RcOTdMMsueqRHToralElN4T4cOCgB3CJkSx4hegiYwY82JPz_LBf_SPiyAlhcV7ADWqZtjiVeKyyVBnuzX8L9DnLNeZm0Vr8AyZrcnQ</recordid><startdate>20090331</startdate><enddate>20090331</enddate><creator>Li, Xinjun</creator><creator>Sundquist, Jan</creator><creator>Hemminki, Kari</creator><creator>Sundquist, Kristina</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20090331</creationdate><title>Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden</title><author>Li, Xinjun ; Sundquist, Jan ; Hemminki, Kari ; Sundquist, Kristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-35857db7323b218ab4e6b379712ee779328da5d9a06c07b9140314e1b2d3f4a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Familial aggregation</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Heritability</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Population-based</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Psychotic Disorders - genetics</topic><topic>Registries</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><topic>Sex Factors</topic><topic>Sibling risk</topic><topic>Siblings</topic><topic>Social Environment</topic><topic>Sweden</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xinjun</creatorcontrib><creatorcontrib>Sundquist, Jan</creatorcontrib><creatorcontrib>Hemminki, Kari</creatorcontrib><creatorcontrib>Sundquist, Kristina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xinjun</au><au>Sundquist, Jan</au><au>Hemminki, Kari</au><au>Sundquist, Kristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2009-03-31</date><risdate>2009</risdate><volume>166</volume><issue>1</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract Familial risks of psychotic disorders and schizophrenia have been assessed in previous studies. However, the degree of familial clustering in large population datasets remains to be established. We conducted a study on familial risks of psychotic disorders and schizophrenia by linking the Multigeneration Register to the nationwide Swedish Hospital Discharge Register. All patients younger than 72 years hospitalized for psychotic disorders or schizophrenia between 1987 and 2004 were included. Standardized incidence ratios (SIRs) were calculated for individuals with affected singleton siblings, twins or spouses compared with individuals whose siblings or spouses had no hospitalization for psychotic disorders or schizophrenia. A total of 40,228 hospitalized cases were identified of which 3006 were affected sibling pairs. The overall significant familial SIRs were 4.82 for psychotic disorders and 7.34 for schizophrenia. The highest SIRs were found in the younger ages. There were no significant gender differences. The significant SIR for psychotic disorders among twin pairs was 6.40 and the significant SIRs for psychotic disorders among spouses varied between 3.17 and 3.29. Age difference between siblings had no effect on the magnitude of the SIRs. The findings of the present large-scale study suggest that heritable factors have a stronger effect on psychotic disorders and schizophrenia than environmental factors. Future studies could coordinate epidemiological studies of large populations with molecular biology resources.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>19208442</pmid><doi>10.1016/j.psychres.2007.12.003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Age Factors Aged Biological and medical sciences Cross-Sectional Studies Familial aggregation Female Genetic Predisposition to Disease - genetics Heritability Hospitalization - statistics & numerical data Humans Incidence Male Medical sciences Middle Aged Population-based Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - epidemiology Psychotic Disorders - genetics Registries Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics Sex Factors Sibling risk Siblings Social Environment Sweden Young Adult |
| title | Familial risks of psychotic disorders and schizophrenia among siblings based on hospitalizations in Sweden |
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