Suramin inhibits the CD40–CD154 costimulatory interaction: A possible mechanism for immunosuppressive effects

Suramin is a symmetric polysulfonated naphthylamine–benzamide urea derivative approved for the treatment of trypanosomiasis and onchocerciasis and a known P2 (ATP/UTP purine receptor) antagonist. Here, we report its ability to inhibit the important CD40–CD154 costimulatory interaction required for T...

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Veröffentlicht in:	Biochemical pharmacology 2009-04, Vol.77 (7), p.1236-1245
Hauptverfasser:	Margolles-Clark, Emilio, Jacques-Silva, M. Caroline, Ganesan, Lakshmi, Umland, Oliver, Kenyon, Norma S., Ricordi, Camillo, Berggren, Per-Olof, Buchwald, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CD40 Antigens - antagonists & inhibitors CD40 Antigens - immunology CD40 Antigens - metabolism CD40 ligand CD40 Ligand - antagonists & inhibitors CD40 Ligand - immunology CD40 Ligand - metabolism Cell Proliferation - drug effects Cells, Cultured Costimulation Humans Immunosuppression Immunosuppressive Agents - pharmacology Medical sciences Medicin och hälsovetenskap Mice Pharmacology. Drug treatments Protein Binding - drug effects Protein Binding - physiology Protein–protein interaction Suramin Suramin - pharmacology
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