PDGF-C and -D and their receptors PDGFR-α and PDGFR-β in atherosclerotic human arteries

Background Platelet derived growth factors (PDGFs) are mitogens for fibroblasts and smooth muscle cells. This growth factor family contains four members PDGF‐A, PDGF‐B, PDGF‐C and PDGF‐D. Biology of recently discovered PDGF‐C and PDGF‐D is not well‐established. Here we studied the expression of PDG...

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Veröffentlicht in:	European journal of clinical investigation 2009-04, Vol.39 (4), p.320-327
Hauptverfasser:	Karvinen, H., Rutanen, J., Leppänen, O., Lach, R., Levonen, A.-L., Eriksson, U., Ylä-Herttuala, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Arteries - metabolism Arteries - pathology Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerotic lesion Female gene expression Humans Immunohistochemistry - methods immunohistology Male Middle Aged platelet derived growth factor Platelet-Derived Growth Factor - immunology Platelet-Derived Growth Factor - metabolism Receptor, Platelet-Derived Growth Factor alpha - immunology Receptor, Platelet-Derived Growth Factor alpha - metabolism Receptor, Platelet-Derived Growth Factor beta - immunology Receptor, Platelet-Derived Growth Factor beta - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism
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