T Cell-Mediated Inflammation in Adipose Tissue Does Not Cause Insulin Resistance in Hyperlipidemic Mice

Obesity is associated with chronic inflammation in adipose tissue. Proinflammatory cytokines including tumor necrosis factor-alpha and interleukin-6 secreted by adipose tissue during the metabolic syndrome are proposed to cause local and general insulin resistance and promote development of type 2 d...

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Veröffentlicht in:	Circulation research 2009-04, Vol.104 (8), p.961-968
Hauptverfasser:	SULTAN, Ariane, STRODTHOFF, Daniela, ZIERATH, Juleen R, ARNER, Peter, HANSSON, Goran K, ROBERTSON, Anna-Karin, PAULSSON-BERNE, Gabrielle, FAUCONNIER, Jeremy, PARINI, Paolo, RYDEN, Mikael, THIERRY-MIEG, Nicolas, JOHANSSON, Maria E, CHIBALIN, Alexander V
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism Adipokines - metabolism Adipose Tissue Adipose Tissue, White - immunology Adipose Tissue, White - physiopathology Animal Animals Antigens Apolipoproteins E - deficiency Apolipoproteins E - genetics Apolipoproteins E/deficiency/genetics Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - physiopathology Atherosclerosis/genetics/immunology/physiopathology Biological and medical sciences Blood Glucose - metabolism Body Weight CD4 Antigens - genetics CD4-Positive T-Lymphocytes - immunology CD4/genetics Chemokine CCL2 - metabolism Disease Models Disease Models, Animal Disorders of blood lipids. Hyperlipoproteinemia Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genetic Hydrocortisone - metabolism Hyperlipidemias - genetics Hyperlipidemias - immunology Hyperlipidemias - physiopathology Hyperlipidemias/genetics/immunology/physiopathology Immunologi inom det medicinska området Immunology in the medical area Inbred C57BL Inflammation - genetics Inflammation - immunology Inflammation - physiopathology Inflammation Mediators - metabolism Inflammation/genetics/immunology/physiopathology Insulin Resistance Interferon-gamma - metabolism Interleukin-6 - metabolism Knockout Lipogenesis Medical sciences Medicin och hälsovetenskap Metabolic diseases Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Promoter Regions Promoter Regions, Genetic Protein-Serine-Threonine Kinases - genetics Receptors Receptors, Transforming Growth Factor beta - genetics Time Factors Transforming Growth Factor beta/genetics Transgenic Tumor Necrosis Factor-alpha - metabolism Vertebrates: cardiovascular system White/immunology/physiopathology
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